Resistance to Endotoxin Shock in Spontaneously Hypertensive Rats

Septic shock involves systemic vasodilation mediated by proinflammatory cytokines. In essential hypertension, vascular and immune dysfunctions are closely associated. The response of hypertensive animals compared with normotensive controls to endotoxin (lipopolysaccharide; LPS) challenge is not know...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1998-06, Vol.31 (6), p.1350-1356
Main Authors: Bernard, Catherine, Merval, Regine, Esposito, Bruno, Tedgui, Alain
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents - pharmacology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Experimental diseases
Hydralazine - pharmacology
Immunity, Innate
Injections, Intravenous
Interleukin-6 - blood
Lipopolysaccharides - administration & dosage
Male
Medical sciences
Rats
Rats, Inbred SHR - physiology
Rats, Inbred WKY
Shock, Septic - blood
Shock, Septic - immunology
Shock, Septic - mortality
Time Factors
Tumor Necrosis Factor-alpha - analysis
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Summary:Septic shock involves systemic vasodilation mediated by proinflammatory cytokines. In essential hypertension, vascular and immune dysfunctions are closely associated. The response of hypertensive animals compared with normotensive controls to endotoxin (lipopolysaccharide; LPS) challenge is not known. Age-matched (12 weeks) normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were exposed to intravenous injection of 10 mg/kg LPS. Survival rate at 24 hours was markedly higher in SHR than in WKY (12 of 15 and 3 of 15, respectively; P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.31.6.1350