ASPERFURAN, A NOVEL ANTIFUNGAL METABOLITE FROM ASPERGILLUS ORYZAE

Asperfuran is a novel antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibited chitin synthase from Coprinus cinereus. This inhibition could be abolished by the addition of egg lecithin. In the agar diffusion assay asperfuran induced morphologic...

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Bibliographic Details
Published in:Journal of antibiotics 1990/06/25, Vol.43(6), pp.648-654
Main Authors: PFEFFERLE, W., ANKE, H., BROSS, M., STEFFAN, B., VIANDEN, R., STEGLICH, W.
Format: Article
Language:English
Subjects:
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antifungal Agents - analysis
Antifungal Agents - biosynthesis
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Applied microbiology
Aspergillus - metabolism
Aspergillus oryzae
Aspergillus oryzae - classification
Aspergillus oryzae - metabolism
Benzofurans - analysis
Benzofurans - isolation & purification
Benzofurans - metabolism
Benzofurans - pharmacology
Biological and medical sciences
Chitin Synthase - antagonists & inhibitors
Coprinus cinereus
Fundamental and applied biological sciences. Psychology
Fungi - drug effects
Glucosyltransferases - antagonists & inhibitors
Magnetic Resonance Spectroscopy
Microbiology
Molecular Structure
Mucor - drug effects
Mucor - metabolism
Mucor miehei
Oxygen Consumption - drug effects
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Summary:Asperfuran is a novel antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibited chitin synthase from Coprinus cinereus. This inhibition could be abolished by the addition of egg lecithin. In the agar diffusion assay asperfuran induced morphological changes in Mucor miehei at very low concentrations (20 ng/disc) while growth was only partly inhibited. In HeLa S3 and L1210 cells it showed weak cytotoxicity, the IC50 was 25 μg/ml.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.43.648