Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions

Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Generation of nitric oxide is not detectable under norm...

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Bibliographic Details
Published in:FEBS letters 1998-05, Vol.427 (2), p.225-228
Main Authors: Millar, Timothy M, Stevens, Cliff R, Benjamin, Nigel, Eisenthal, Robert, Harrison, Roger, Blake, David R
Format: Article
Language:English
Subjects:
Animals
Cattle
Enzyme Inhibitors - pharmacology
GTN, glyceryl trinitrate
Kinetics
NAD - metabolism
Nitrate
Nitrates - metabolism
Nitric oxide
Nitric Oxide - biosynthesis
Nitrite
Nitroglycerin - metabolism
NO, nitric oxide
Oxygen
Oxypurinol - pharmacology
Sodium Nitrite - metabolism
Triazines - pharmacology
Xanthine Oxidase - antagonists & inhibitors
Xanthine Oxidase - metabolism
Xanthine oxidoreductase
XOR, xanthine oxidoreductase
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Summary:Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Generation of nitric oxide is not detectable under normoxic conditions and is inhibited by the molybdenum site-specific inhibitors, oxypurinol and (−)BOF 4272. These enzymic reactions provide a mechanism for generation of NO under hypoxic conditions where nitric oxide synthase does not function, suggesting a vasodilatory role in ischaemia.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(98)00430-X