Conduction pathways of motor evoked potentials following transcranial magnetic stimulation: A rodent study using a "Figure-8" coil

We have examined the conduction pathways of motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation, and their correlation with locomotor function in rats. MEPs were concomitantly recorded from the spinal cord (sMEPs) and the limb muscles (mMEPs) before and after various spinal...

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Bibliographic Details
Published in:Muscle & nerve 1998-06, Vol.21 (6), p.722-731
Main Authors: Kamida, Tohru, Fujiki, Minoru, Hori, Shigeaki, Isono, Mitsuo
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Electromagnetic Phenomena - methods
Evoked Potentials, Motor - physiology
extrapyramidal system
Extrapyramidal Tracts - physiology
figure-8 coil
Forelimb - physiology
Fundamental and applied biological sciences. Psychology
Hindlimb - physiology
magnetic stimulation
Male
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
motor evoked potentials
Muscle, Skeletal - physiology
rat
Rats
Rats, Wistar
Spinal Cord Injuries - physiopathology
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
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Summary:We have examined the conduction pathways of motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation, and their correlation with locomotor function in rats. MEPs were concomitantly recorded from the spinal cord (sMEPs) and the limb muscles (mMEPs) before and after various spinal tract ablations. Motor function was also examined using an inclined plane test. sMEPs were composed of four negative peaks (N1–N4) and mMEPs of high‐voltage, biphasic waves. Ventral funiculus transection reduced the N1–N3 peaks and abolished mMEPs. Contrarily, dorsal funiculus transection including the pyramidal tract did not alter these MEPs. Motor performance on an inclined plane was worse after ventral funiculus transection than after other transections. These findings indicate that, in rats, the N1–N3 peaks of magnetic sMEPs conduct ventral funiculus activity, and that magnetic mMEPs mainly reflect extrapyramidal activities and are correlated with locomotor function. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:722–731, 1998.
ISSN:0148-639X
1097-4598
DOI:10.1002/(SICI)1097-4598(199806)21:6<722::AID-MUS3>3.0.CO;2-9