INTERFERON-α PRIMES EARLY PROLIFERATIVE RESPONSE OF BONE MARROW CELLS IN VIVO

Using colony-forming assays, a number of previous studies established that interferon α (IFN-α) could cause bone marrow cell (BMC) suppression. In this study, the suppressive effect of IFN-α is however shown to be time-dependent, occurring only 7–8 days after transfer of BMC obtained from IFN-α-trea...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 1998-03, Vol.10 (3), p.185-191
Main Authors: Pretnar, Gorazd, Steindl, Franz, Meager, Anthony, Thorpe, Robin, Borth, Nicole, Schmatz, Christine, Metzger, Rainer, Katinger, Hermann W.D., Ferlan, Igor
Format: Article
Language:English
Subjects:
activation/bone marrow cells/haematopoiesis/granulocyte-macrophage colony-stimulating factor/macrophage colony-stimulating factor/interferon α
Animals
Bone Marrow Cells - cytology
Bone Marrow Cells - drug effects
Cell Division
Cells, Cultured
Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology
Humans
Interferon Type I - pharmacology
Macrophage Colony-Stimulating Factor - pharmacology
Mice
Mice, Inbred C57BL
Recombinant Proteins
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Summary:Using colony-forming assays, a number of previous studies established that interferon α (IFN-α) could cause bone marrow cell (BMC) suppression. In this study, the suppressive effect of IFN-α is however shown to be time-dependent, occurring only 7–8 days after transfer of BMC obtained from IFN-α-treated mice to growth factor-containing culture medium. In contrast, in the interval before suppression is observed, BMC obtained from IFN-α-treated mice initially proliferated more rapidly than BMC from placebo-treated mice. These findings suggest that IFN-α acts in vivo to prime the proliferative responses of BMC, a hitherto unexpected action which may have clinical relevance.
ISSN:1043-4666
1096-0023
DOI:10.1006/cyto.1997.0274