Cannabinoid modulation of intestinal propulsion in mice

The effect of cannabinoid receptor activation and blockade on the propulsive activity in the mouse small intestine was assessed in the present study by measuring the transit of an orally administered, non-absorbable marker. The cannabinoid receptor agonist WIN 55,212-2 ( R(+)-[2,3-dihydro-5-methyl-3...

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Bibliographic Details
Published in:European journal of pharmacology 1998-02, Vol.344 (1), p.67-69
Main Authors: Colombo, Giancarlo, Agabio, Roberta, Lobina, Carla, Reali, Roberta, Gessa, Gian Luigi
Format: Article
Language:English
Subjects:
Animals
Benzoxazines
Biological and medical sciences
Cannabinoid CB 1 receptor
Cannabinoids - antagonists & inhibitors
Digestive system
Gastrointestinal Transit - drug effects
Intestinal propulsive activity
Male
Medical sciences
Mice
Mice, Inbred ICR
Morpholines - pharmacology
Mouse
Naphthalenes - pharmacology
Pharmacology. Drug treatments
Piperidines - pharmacology
Pyrazoles - pharmacology
Receptors, Cannabinoid
Receptors, Drug - agonists
Receptors, Drug - antagonists & inhibitors
Receptors, Drug - physiology
Rimonabant
Small intestine
SR 141716A
WIN 55,212-2
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Summary:The effect of cannabinoid receptor activation and blockade on the propulsive activity in the mouse small intestine was assessed in the present study by measuring the transit of an orally administered, non-absorbable marker. The cannabinoid receptor agonist WIN 55,212-2 ( R(+)-[2,3-dihydro-5-methyl-3[(morpholinyl)methyl]pyrrolo[1,2,3-de-1,4benzoxazin-yl]-(1-naphthalenyl)methanone mesylate) inhibited, while the selective cannabinoid CB 1 receptor antagonist SR 141716A ( N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole-carboxamide) stimulated the marker transit. Furthermore, a per se non-effective dose of SR 141716A reversed WIN 55,212-2-induced reduction of the transit. The results of the present study suggest a role for cannabinoid CB 1 receptors in the control of propulsive activity in the mouse small intestine.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(97)01555-0