Granule cell dispersion is correlated with early epileptic events in human temporal lobe epilepsy

Granule cell dispersion (GCD) into the dentate gyrus (DG) molecular layer was observed in hippocampal specimens in 10 out of 22 cases of human non-lesional temporal lobe epilepsy (TLE) and was associated with hippocampal sclerosis (HS). The presence of GCD was significantly linked to events of epile...

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Bibliographic Details
Published in:Journal of the neurological sciences 1998-02, Vol.154 (2), p.133-136
Main Authors: Lurton, Dominique, El Bahh, Bouchaib, Sundstrom, Lars, Rougier, Alain
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Death
Child
Dentate Gyrus - pathology
Diffuse Cerebral Sclerosis of Schilder - pathology
Dispersion
Epilepsy
Epilepsy, Temporal Lobe - pathology
Granule cells
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampus
Humans
Medical sciences
Morphometric analysis
Nervous system (semeiology, syndromes)
Neurology
Neurons - pathology
Statistics, Nonparametric
Time Factors
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Summary:Granule cell dispersion (GCD) into the dentate gyrus (DG) molecular layer was observed in hippocampal specimens in 10 out of 22 cases of human non-lesional temporal lobe epilepsy (TLE) and was associated with hippocampal sclerosis (HS). The presence of GCD was significantly linked to events of epileptic nature arising during the first 4 years of life but not with the durations of epilepsy, nor the number of seizures. Dispersion could be induced by seizure-linked structural plasticity occurring during a specific early permissive period.
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(97)00220-7