CHARGE Association: An Update and Review for the Primary Pediatrician

CHARGE association is a nonrandom pattern of congenital anomalies that occurs together more frequently than one would expect on the basis of chance. This common multiple anomaly condition has an estimated prevalence of 1:10,000. The number of children diagnosed with CHARGE association is increasing,...

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Bibliographic Details
Published in:Clinical Pediatrics 1998-03, Vol.37 (3), p.159-173
Main Authors: Blake, Kim D., Davenport, Sandra L. H., Hall, Bryan D., Hefner, Margaret A., Pagon, Roberta A., Williams, Marc S., Lin, Angela E., Graham, John M.
Format: Article
Language:English
Subjects:
Abnormalities, Multiple - epidemiology
Abnormalities, Multiple - physiopathology
Abnormalities, Multiple - psychology
Biological and medical sciences
Child
Child, Preschool
Complex syndromes
Developmental Disabilities - epidemiology
Developmental Disabilities - etiology
Female
Genetics
Humans
Infant
Male
Medical diagnosis
Medical genetics
Medical sciences
Pediatrics
Physicians
Primary Health Care
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Summary:CHARGE association is a nonrandom pattern of congenital anomalies that occurs together more frequently than one would expect on the basis of chance. This common multiple anomaly condition has an estimated prevalence of 1:10,000. The number of children diagnosed with CHARGE association is increasing, owing presumably to greater awareness of this condition and advances in the care of complex, chronically ill children, resulting in improved survival and outcome. This review of ClHARGE association presents diagnostic criteria that may define a concise, recognizable syndrome with a single pathogenetic basis. This review also summarizes our current understanding of the management for this complex and chronic multiple congenital anomaly condition and discusses the pathogenetic basis for this condition.
ISSN:0009-9228
1938-2707
DOI:10.1177/000992289803700302