Cerebral magnetic resonance imaging in patients with or without antiphospholipid antibodies

Objective: To determine in patients with systemic lupus erythematosus (SLE) or with primary antiphospholipid syndrome (PAPS) the prevalence of cerebral magnetic resonance imaging changes (MRI) and the relationship with antiphospholipid antibodies. Methods: Twenty-nine consecutive SLE patients, 24 PA...

Full description

Saved in:
Bibliographic Details
Published in:Lupus 1998-01, Vol.7 (2), p.124-131
Main Authors: Hachulla, E, Michon-Pasturel, U, Leys, D, Pruvo, J-P, Queyrel, V, Masy, E, Arvieux, J, Caron, C, Brevet-Coupeé, F, Hatron, P-Y, Devulder, B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies, Anticardiolipin - analysis
Antibodies, Antiphospholipid - immunology
Antiphospholipid Syndrome - diagnosis
Antiphospholipid Syndrome - immunology
Atrophy
Autoantibodies - analysis
Autoantibodies - immunology
beta 2-Glycoprotein I
Brain - immunology
Brain - pathology
Brain - physiopathology
Cerebral Infarction - pathology
Female
Glycoproteins - immunology
Humans
Immunoglobulin G - analysis
Immunoglobulin G - immunology
Immunoglobulin M - analysis
Immunoglobulin M - immunology
Logistic Models
Lupus Coagulation Inhibitor - analysis
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - immunology
Magnetic Resonance Imaging
Male
Middle Aged
Multivariate Analysis
Risk Factors
Severity of Illness Index
Thrombosis - diagnosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To determine in patients with systemic lupus erythematosus (SLE) or with primary antiphospholipid syndrome (PAPS) the prevalence of cerebral magnetic resonance imaging changes (MRI) and the relationship with antiphospholipid antibodies. Methods: Twenty-nine consecutive SLE patients, 24 PAPS patients and 31 healthy controls were prospectively included in the study and underwent MRI Scan over a 1-year period. MRI scans were analyzed separately by a neuroradiologist for white matter changes [periventricular hyperintensity (PVH) (0–6 scale), deep white matter hyperintensity (WMH) (0–24 scale)], and one neurologist for cerebral atrophy (0–39 scale) and stroke subtypes. Statistical assessment consisted of a discriminant analysis performed with SAS-package with MRI data as dependent variables and, as independent variables, age, sex, arterial hypertension, diabetes mellitus, cardiopathy, migraine, neurological symptoms, antiphospholipid antibodies, SLE, steroid treatment. Results: The prevalence of cerebral atrophy was increased in both SLE and PAPS groups relative to controls. PVH and WMH scores were significantly higher in SLE and PAPS than in controls. Focal infarct did not differ in the SLE group when compared with PAPS. PVH and WMH scores were significantly higher in patients with neurological symptoms. Using a correlation test we found a weak significant correlation between cerebral atrophy and lupus anticoagulant. The multivariate analysis found only three independent variables related to PVH and WMH: age, the diagnosis of SLE and cerebral atrophy. Conclusions: Age, presence of SLE and presence of neurological symptoms were independently related with WMH and PVH, but not antiphospholipid antibodies.
ISSN:0961-2033
1477-0962
DOI:10.1191/096120398678919868