Thyroid C cells of middle-aged rats treated with estradiol or calcium

The structure and function of C cells of middle-aged female rats (14-months old) treated with estradiol dipropionate (EDP), calcium (Ca) or a combination of EDP+Ca were studied. A stereological method was used to determine the volume of calcitonin (CT)-immunoreactive C cells and their nuclei, and th...

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Bibliographic Details
Published in:Histochemistry and cell biology 1998-03, Vol.109 (3), p.257-262
Main Authors: Sekulić, M, Lovren, M, Milosević, V, Mićić, M, Balint-Perić, L
Format: Article
Language:English
Subjects:
17β-Estradiol
Animals
Body weight
Body Weight - drug effects
C cells
Calcitonin
Calcium
Calcium - pharmacology
Degranulation
Estradiol - analogs & derivatives
Estradiol - pharmacology
Female
Immunoenzyme Techniques
Immunoreactivity
Middle age
Osteocalcin
Parathyroid
Parathyroid hormone
Rats
Rats, Wistar
Rodents
Serum levels
Statistical analysis
Structure-function relationships
Thyroid
Thyroid Gland - cytology
Thyroid Gland - drug effects
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Summary:The structure and function of C cells of middle-aged female rats (14-months old) treated with estradiol dipropionate (EDP), calcium (Ca) or a combination of EDP+Ca were studied. A stereological method was used to determine the volume of calcitonin (CT)-immunoreactive C cells and their nuclei, and the relative volume density and mean number of the C cells per section were calculated. Serum levels of CT, osteocalcin, parathyroid hormone (PTH), and beta-estradiol were also measured. A significant decrease in body weight of the rats treated with EDP or EDP+Ca was observed. These treatments led to a significant decrease in cellular and nuclear volumes, relative volume density, and mean number of C cells per section, in comparison with the corresponding controls. A reduction of the serum level of CT, PTH, and osteocalcin was also recorded in EDP- and EDP+Ca-treated animals. No statistically significant differences between Ca- and vehicle-injected rats, with regard to all morphometric C cell parameters and biochemical values determined, were seen. However, a conspicuous degranulation of the C cells and decreased immunoreactivity for CT in the Ca-receiving group, which could be interpreted as the signs of increased activity of these cells, were noticed. This effect of Ca was also observed in rats injected with EDP and Ca in combination, when the inhibitory effect of EDP on C cell function was less noticeable than in the group treated with EDP alone.
ISSN:0948-6143
1432-119X
DOI:10.1007/s004180050225