Pelvic Adhesions Contain Sex Steroid Receptors and Produce Angiogenesis Growth Factors

Objective: To evaluate female pelvic adhesion tissue for the presence of estrogen receptor (ER), progesterone receptor (PR), basic fibroblastic growth factor (basic-FGF), and vascular endothelial growth factor (VEGF). Design: Descriptive study. Setting: Patients at a tertiary medical center. Patient...

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Bibliographic Details
Published in:Fertility and sterility 1998-03, Vol.69 (3), p.511-516
Main Authors: Wiczyk, Halina P, Grow, Daniel R, Adams, Lorrie A, O’Shea, Donna L, Reece, Margaret T
Format: Article
Language:English
Subjects:
Adhesions
Adult
Biological and medical sciences
Endometriosis - metabolism
Endometriosis - pathology
Endothelial Growth Factors - analysis
Endothelium, Vascular - chemistry
estradiol and progesterone receptors
Female
Female genital diseases
Fibroblast Growth Factor 2 - analysis
Fibroblasts - chemistry
growth factors
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Lymphokines - analysis
Medical sciences
Muscle, Smooth, Vascular - chemistry
Non tumoral diseases
Peritoneal Diseases - metabolism
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Tissue Adhesions - metabolism
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
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Summary:Objective: To evaluate female pelvic adhesion tissue for the presence of estrogen receptor (ER), progesterone receptor (PR), basic fibroblastic growth factor (basic-FGF), and vascular endothelial growth factor (VEGF). Design: Descriptive study. Setting: Patients at a tertiary medical center. Patients: Female reproductive age patients undergoing gynecologic surgery who were not receiving hormonal therapy. Interventions: Female reproductive tract peritoneal adhesion tissue was excised, frozen, and sent for immunohistologic evaluation. Main Outcome Measure: Presence of ER, PR, basic-FGF, and VEGF in adhesion tissue. Results: Nineteen of 19 specimens were positive for PR; 16 of 19 specimens were positive for ER, which was present in a variety of the different cell types constituting adhesion. Vascular endothelial growth factor and basic-FGF were detected in endothelial cells of blood vessels supplying this tissue as well as in mesothelial cells. Conclusion: Adhesion tissue contains ER, PR, and growth factors that may be important in the genesis of the permanent fibrovascular bands between pelvic organs. This supports the theoretical possibility of hormonal manipulation of these tissues to negatively influence postoperative pelvic adhesion formation.
ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(97)00529-3