Antibiotic resistance in Pseudomonas aeruginosa : an Italian survey

In order to assess the current level of resistance to widely used antipseudomonal antibiotics in clinical isolates of Pseudomonas aeruginosa, a national survey was undertaken. Fifteen hospitals throughout Italy participated in the study. The University of Catania tested the antibiotic susceptibility...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1998-02, Vol.41 (2), p.307-310
Main Authors: BONFIGLIO, G, CARCIOTTO, V, RUSSO, G, STEFANI, S, SCHITO, G. C, DEBBIA, E, NICOLETTI, G
Format: Article
Language:English
Subjects:
Amikacin - pharmacology
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
beta-Lactam Resistance
Biological and medical sciences
Ceftazidime - pharmacology
Ciprofloxacin - pharmacology
Drug Resistance, Microbial
Humans
Imipenem - pharmacology
Intensive Care Units
Italy
Medical sciences
Meropenem
Microbial Sensitivity Tests
Oxidoreductases - metabolism
Penicillin Resistance
Pharmacology. Drug treatments
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - physiology
Pyocyanine - metabolism
Thienamycins - pharmacology
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Summary:In order to assess the current level of resistance to widely used antipseudomonal antibiotics in clinical isolates of Pseudomonas aeruginosa, a national survey was undertaken. Fifteen hospitals throughout Italy participated in the study. The University of Catania tested the antibiotic susceptibility of 1005 consecutive clinically significant P. aeruginosa collected from March to June 1995. Lack of susceptibility, according to NCCLS breakpoints, was at the following rates: meropenem, 9.1%; imipenem, 19.3%; ceftazidime, 13.4%; carbenicillin, 27.3%; piperacillin, 12%; ticarcillin/clavulanic acid, 22.8%; amikacin, 10.6%; and ciprofloxacin, 31.9%. About half of the isolates (44.4%) were not susceptible to at least one of the antibiotics tested.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/41.2.307