Influence of intrauterine growth retardation on parameters of liver function in low birth weight infants

To establish nutritional management of low birth-weight infants according to their individual metabolic situation, hepatocellular partial function was studied in 13 appropriate (AGA) and 11 small-for-gestational-age (SGA) low birthweight (LBW) infants during the first weeks of postnatal life. The co...

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Bibliographic Details
Published in:European journal of pediatrics 1990-03, Vol.149 (6), p.396-398
Main Authors: Boehm, G, Müller, D M, Teichmann, B, Krumbiegel, P
Format: Article
Language:English
Subjects:
Acetamides - urine
Amines - blood
Bile Acids and Salts - blood
Female
Fetal Growth Retardation - metabolism
Humans
Infant
Infant Nutritional Physiological Phenomena
Infant, Low Birth Weight - metabolism
Infant, Newborn
Infant, Small for Gestational Age - metabolism
Liver - metabolism
Male
Nitrogen - blood
Nitrogen - urine
Nitrogen Isotopes
Pregnancy
Steroid Hydroxylases - blood
Urea - urine
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Summary:To establish nutritional management of low birth-weight infants according to their individual metabolic situation, hepatocellular partial function was studied in 13 appropriate (AGA) and 11 small-for-gestational-age (SGA) low birthweight (LBW) infants during the first weeks of postnatal life. The concentrations of total bile acids and of alpha-amino-nitrogen in serum, the renal excretion of urea and ammonia and the renal excretion of 15N after enteral administration of 3 mg 15N-labeled methacetin/kg were measured. In comparison to AGA infants, SGA infants had elevated serum concentrations of total bile acids and of alpha-amino-nitrogen, decreased excretion of urea, increased excretion of ammonia in urine, and lower urinary 15N-excretion after enteral administration of 15N-labeled methacetin. The data suggest that hepatocellular functions are influenced by intrauterine growth retardation resulting in a reduced metabolic capacity in SGA infants. The metabolic differences between SGA and AGA infants should be considered in the nutritional management of LBW infants.
ISSN:0340-6199
1432-1076
DOI:10.1007/bf02009657