Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study

To assess the relationship between two phenotypes in an extremely well‐characterized population of personality disorder patients–impulsive aggression and prolactin response to fenfluramine–and tryptophan hydroxylase (TPH) genotype, TPH genotype (at an intronic polymorphic site) and prolactin respons...

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Bibliographic Details
Published in:American journal of medical genetics 1998-02, Vol.81 (1), p.13-17
Main Authors: New, Antonia S., Gelernter, Joel, Yovell, Yoram, Trestman, Robert L., Nielsen, David A., Silverman, Jeremy, Mitropoulou, Vivian, Siever, Larry J.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aggression - psychology
Biological and medical sciences
Female
Fenfluramine
genetics
Genotype
Humans
Impulsive Behavior - enzymology
Impulsive Behavior - genetics
Male
Medical sciences
personality disorders
polymorphism
Prolactin - blood
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
serotonin
Serotonin - biosynthesis
Serotonin Uptake Inhibitors
Social behavior disorders. Criminal behavior. Delinquency
Tryptophan Hydroxylase - genetics
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Summary:To assess the relationship between two phenotypes in an extremely well‐characterized population of personality disorder patients–impulsive aggression and prolactin response to fenfluramine–and tryptophan hydroxylase (TPH) genotype, TPH genotype (at an intronic polymorphic site) and prolactin response to fenfluramine were assessed in 40 Caucasian patients with personality disorder. Impulsive aggression was assessed by using the Buss‐Durkee Hostility Inventory (BDHI). Twenty‐one male patients with the “LL” genotype had higher BDHI scores than men with the “UL” or the “UU” genotype. No relationship between genotype and prolactin response to fenfluramine was found. It was concluded that impulsive‐aggressive behavior in male personality disorder patients may be associated with the TPH genotype. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:13–17, 1998. © 1998 Wiley‐Liss, Inc.
ISSN:0148-7299
1096-8628
DOI:10.1002/(SICI)1096-8628(19980207)81:1<13::AID-AJMG3>3.0.CO;2-O