β-CCM Inhibits Muricide Induced by Olfactory Bulbectomy in Rats

Intravenous administration of β-CCM (methyl-β-carboline-3-carboxylate) at doses ranging from 0.3 to 10 mg/kg dose-dependently inhibited muricide in olfactory bulbectomized rats. β-CCM elicited a decrease of locomotor activity at doses ranging from 0.3 to 3 mg/kg, and it impaired rotarod performance...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1990, Vol.52(3), pp.441-447
Main Authors: NAGATANI, Tadashi, YAMAMOTO, Tsuneyuki, TAKAO, Katsuyuki, SUGIHARA, Taisuke, UEKI, Showa
Format: Article
Language:English
Subjects:
Aggression - drug effects
Animals
Biological and medical sciences
Brain - anatomy & histology
Carbolines - pharmacology
Diazepam - pharmacology
Dose-Response Relationship, Drug
Flumazenil - pharmacology
Injections, Intravenous
Male
Medical sciences
Mice
Motor Activity - drug effects
Muscle Relaxants, Central
Neuropharmacology
Olfactory Bulb - physiology
Pharmacology. Drug treatments
Phenoxybenzamine - pharmacology
Postural Balance - drug effects
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Inbred Strains
Receptors, GABA-A - drug effects
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Summary:Intravenous administration of β-CCM (methyl-β-carboline-3-carboxylate) at doses ranging from 0.3 to 10 mg/kg dose-dependently inhibited muricide in olfactory bulbectomized rats. β-CCM elicited a decrease of locomotor activity at doses ranging from 0.3 to 3 mg/kg, and it impaired rotarod performance at doses of 1 and 3 mg/kg. The inhibition of muricide induced by β-CCM was antagonized by intraperitoneal administration of Rol 5-1788 at 10 mg/kg or diazepam at 3 mg/kg. However, the hypolocomotor activity and impairment of rotarod performance induced by β-CCM were not antagonized by diazepam at 3 mg/kg. These results indicated that β-CCM exerts an inhibitory effect on muricide through benzodiazepine receptors and this inhibitory effect was not solely caused by its sedative or motor incordinating activity at the dose ranges used in this study.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.52.441