Morphometric analysis of gastrectomy-evoked osteopenia

Gastrectomy leads to osteopenia in the rat. The present study describes the effects of gastrectomy on bone morphology. Rats were subjected to gastrectomy or sham operation. Four weeks after the operation the rats were killed and both tibiae were removed. Bone morphology of the left tibia was analyze...

Full description

Saved in:
Bibliographic Details
Published in:Calcified tissue international 1998-04, Vol.62 (4), p.323-326
Main Authors: Mühlbauer, R C, Schenk, R K, Chen, D, Lehto-Axtelius, D, Hâkanson, R
Format: Article
Language:English
Subjects:
Animals
Body Weight - physiology
Bone and Bones - chemistry
Bone Density - physiology
Bone Diseases, Metabolic - etiology
Bone Regeneration
Bone Resorption
Calcification, Physiologic - physiology
Calcitonin - blood
Calcium - blood
Diaphyses - chemistry
Diaphyses - pathology
Diaphyses - physiopathology
Gastrectomy - adverse effects
Gastrins - blood
Male
Osteogenesis - physiology
Parathyroid Hormone - blood
Periosteum - physiopathology
Rats
Rats, Sprague-Dawley
Space life sciences
Tibia - pathology
Tibia - physiopathology
Weight Gain - physiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gastrectomy leads to osteopenia in the rat. The present study describes the effects of gastrectomy on bone morphology. Rats were subjected to gastrectomy or sham operation. Four weeks after the operation the rats were killed and both tibiae were removed. Bone morphology of the left tibia was analyzed with quantitative computer tomography, the right tibia with histomorphometry. Bone length, bone mineral content, as well as indices of bone resorption and formation were measured in the metaphysis and the diaphysis. Gastrectomy had no effect on longitudinal bone growth but it led to a low bone mineral content at both sites. Bone resorption was increased by gastrectomy, as shown by an increase in the medullary cavity area in the diaphysis. Gastrectomy also reduced bone formation, as shown by a decreased periosteal circumference and a decrease in the mean periosteal bone apposition in the diaphysis. In conclusion, gastrectomy-evoked osteopenia reflects impaired formation and increased resorption of bone.
ISSN:0171-967X
1432-0827
DOI:10.1007/s002239900439