Association of organic solvent tolerance and fluoroquinolone resistance in clinical isolates of Escherichia coli

Fluoroquinolone resistance in Escherichia coli is principally caused by two kinds of mutation: those affecting the target proteins of the drugs, i.e. DNA gyrase and topoisomerase IV, and those affecting regulatory genes such as marA, soxS or robA. Recently, overexpression of the latter genes was lin...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1998, Vol.41 (1), p.111-114
Main Authors: OETHINGER, M, KERN, W. V, GOLDMAN, J. D, LEVY, S. B
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cyclohexanes - pharmacology
Drug Resistance, Microbial - genetics
Escherichia coli - drug effects
Fluoroquinolones
Gene Expression Regulation, Bacterial
Genes, Bacterial - genetics
Humans
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Solvents - pharmacology
Statistics as Topic
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fluoroquinolone resistance in Escherichia coli is principally caused by two kinds of mutation: those affecting the target proteins of the drugs, i.e. DNA gyrase and topoisomerase IV, and those affecting regulatory genes such as marA, soxS or robA. Recently, overexpression of the latter genes was linked to increased organic solvent tolerance in E. coli. Among 138 clinical fluoroquinolone-resistant and -susceptible clinical isolates of E. coli we found a high association between fluoroquinolone resistance and organic solvent tolerance. This finding suggests that E. coli may undergo an adaptive response to extrinsic substances other than quinolones, while mutating to fluoroquinolone resistance.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/41.1.111