Antibacterial activity of AM-1155 against penicillin-resistant Streptococcus pneumoniae

AM-1155, a novel fluoroquinolone, exhibited potent activity against Streptococcus pneumoniae, including penicillin-resistant strains; the MIC90 for 48 clinical isolates was 0.25 mg/L. The antibacterial activity of AM-1155 against S. pneumoniae was higher than that of levofloxacin (MIC90 1 mg/L) and...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1998, Vol.41 (1), p.103-106
Main Authors: TOMIZAWA, H, TATEDA, K, MIYAZAKI, S, YAMAGUCHI, K
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Fluoroquinolones
Gatifloxacin
Male
Medical sciences
Mice
Mice, Inbred CBA
Microbial Sensitivity Tests
Penicillin Resistance - physiology
Pharmacology. Drug treatments
Piperazines - administration & dosage
Piperazines - therapeutic use
Pneumococcal Infections - drug therapy
Quinolones - administration & dosage
Quinolones - therapeutic use
Streptococcus pneumoniae - drug effects
Survival Rate
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Summary:AM-1155, a novel fluoroquinolone, exhibited potent activity against Streptococcus pneumoniae, including penicillin-resistant strains; the MIC90 for 48 clinical isolates was 0.25 mg/L. The antibacterial activity of AM-1155 against S. pneumoniae was higher than that of levofloxacin (MIC90 1 mg/L) and comparable with that of sparfloxacin. The MIC90s of penicillin G and erythromycin were 2 and > 4 mg/L, respectively. AM-1155 showed no cross-resistance to penicillin or erythromycin. For experimental murine pneumonia with S. pneumoniae intermediately resistant to penicillin, oral administration of AM-1155 showed efficacy higher than that of levofloxacin and equal to that of sparfloxacin. The efficacy of AM-1155 was also equal to that of subcutaneous penicillin G administration at the same dosage.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/41.1.103