Effects of Forced and Spontaneous Exercise on 8-Hydroxydeoxyguanosine Levels in Rat Organs

We investigated the effects of forced and spontaneous exercise on the levels of 8-hydroxydeoxyguanosine (8-OH-dG), a form of oxidative DNA damage, in rat organs (heart, lung, and liver). Rats were randomly assigned to one of three groups: forced exercise group (F), spontaneous exercise group (S), an...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1998-02, Vol.243 (3), p.678-682
Main Authors: Asami, Shinya, Hirano, Takeshi, Yamaguchi, Raizo, Tsurudome, Yosuke, Itoh, Hideaki, Kasai, Hiroshi
Format: Article
Language:English
Subjects:
Animals
Body Weight
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - metabolism
DNA - metabolism
DNA Damage
Eating
Liver - metabolism
Lung - metabolism
Male
Myocardium - metabolism
Oxidative Stress
Physical Exertion - physiology
Rats
Rats, Sprague-Dawley
Running
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Summary:We investigated the effects of forced and spontaneous exercise on the levels of 8-hydroxydeoxyguanosine (8-OH-dG), a form of oxidative DNA damage, in rat organs (heart, lung, and liver). Rats were randomly assigned to one of three groups: forced exercise group (F), spontaneous exercise group (S), and sedentary control group (C). The mean levels of 8-OH-dG in the F group were 1.9-, 2.1-, and 2.4-fold higher in the heart, lung, and liver DNA, respectively, than in the S group. In the S group of rats, the distance run was not significantly correlated to the 8-OH-dG levels in the heart, lung, and liver DNA. These results demonstrate that the intensity of exercise is an important determinant in DNA damage, and suggest that spontaneous physical exercise is beneficial for maintaining a low level of oxidative DNA damage.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1998.8166