Prognosis in malignant mesothelioma related to MIB 1 proliferation index and histological subtype

The aims of this study were to evaluate the use of the proliferation marker MIB 1 and histological subtype as indicators of prognosis in malignant mesothelioma. Sections from 41 cases of malignant mesothelioma were histologically subtyped on hematoxylin and eosin sections and stained immunohistochem...

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Bibliographic Details
Published in:Human pathology 1998-03, Vol.29 (3), p.246-251
Main Authors: Beer, Trevor W, Buchanan, Rose, Matthews, Alan W, Stradling, Robin, Pullinger, Neil, Pethybridge, Roger J
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - biosynthesis
Antigens, Neoplasm - biosynthesis
Antigens, Nuclear
Biological and medical sciences
Biomarkers, Tumor
Cell Count
Cell Division
Humans
Immunohistochemistry
Ki-67 Antigen - metabolism
Malignant mesothelioma
Medical sciences
Mesothelioma - metabolism
Mesothelioma - mortality
Mesothelioma - pathology
MIB 1
Mitotic Index
Nuclear Proteins - metabolism
Peritoneal Neoplasms - metabolism
Peritoneal Neoplasms - mortality
Peritoneal Neoplasms - pathology
Pleural Neoplasms - metabolism
Pleural Neoplasms - mortality
Pleural Neoplasms - pathology
Pneumology
Prognosis
Proliferation
Survival Analysis
Tumors of the respiratory system and mediastinum
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Summary:The aims of this study were to evaluate the use of the proliferation marker MIB 1 and histological subtype as indicators of prognosis in malignant mesothelioma. Sections from 41 cases of malignant mesothelioma were histologically subtyped on hematoxylin and eosin sections and stained immunohistochemically for the proliferation marker MIB 1. A proliferation index was derived and the results compared with patient survival data. A statistically significant difference was found between the survival of patients having a low and high MIB 1 index ( P < .001). Patients with tumors having a low MIB 1 index lived significantly longer than those with a high MIB 1 index. Patients with the spindle cell histological subtype of malignant mesothelioma had significantly shorter survival times than those with the epithelioid or mixed tumors ( P < .01). The MIB 1 proliferation index and histological tumor subtype are useful markers of prognosis in malignant mesothelioma.
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(98)90043-0