The relationship between MIB-1 proliferation index and outcome in pancreatic neuroendocrine tumors

The expression of the cell-cycle-associated Ki-67 antigen by MIB-1 monoclonal antibody was retrospectively assessed in 35 surgically resected neuroendocrine tumor specimens of the pancreas embedded in paraffin. The MIB-1 proliferation index was correlated with the classification of the neuroendocrin...

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Bibliographic Details
Published in:American journal of clinical pathology 1998-03, Vol.109 (3), p.286-293
Main Authors: PERRET, A. G, MOSNIER, J. F, BUONO, J. P, BERTHELOT, P, CHIPPONI, J, BALIQUE, J. G, CUILLERET, J, DECHELOTTE, P, BOUCHERON, S
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Monoclonal
Antigens, Nuclear
Biological and medical sciences
Cell Count
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Humans
Immunoenzyme Techniques
Immunohistochemistry
Ki-67 Antigen - analysis
Male
Medical sciences
Middle Aged
Mitotic Index
Neoplasm Staging
Neuroendocrine Tumors - chemistry
Neuroendocrine Tumors - classification
Neuroendocrine Tumors - pathology
Nuclear Proteins - analysis
Pancreatic Neoplasms - chemistry
Pancreatic Neoplasms - classification
Pancreatic Neoplasms - pathology
Prognosis
Tumors. Hypoglycemia
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Summary:The expression of the cell-cycle-associated Ki-67 antigen by MIB-1 monoclonal antibody was retrospectively assessed in 35 surgically resected neuroendocrine tumor specimens of the pancreas embedded in paraffin. The MIB-1 proliferation index was correlated with the classification of the neuroendocrine tumors of the pancreas proposed by Klöppel et al. Four prognostic factors showed a significant correlation with MIB-1: local invasion, metastases, tumor differentiation, and production of insulin. However, analysis by the Cox Proportional Hazards Regression Model showed that only local invasion was an independent predictor of outcome. Finally, our study showed a statistically significant increase in the number of deaths and a statistically significant decrease in survival time when the MIB-1 proliferation index was higher than 4%. We conclude that MIB-1 proliferation index is a simple and reliable tool to predict the clinical outcome of the neuroendocrine tumors of the pancreas. The index might be useful for determining the prognosis for an individual because of the significant decrease in survival when the index is higher than 4%.
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/109.3.286