Plant O-methyltransferases: molecular analysis, common signature and classification

Comparative analysis of the predicted amino acid sequences of a number of plant O-methyltransferase cDNA clones show that they share some 32-71% sequence identity, and can be grouped according to the different compounds they utilise as substrates. Five highly conserved regions are proposed as a sign...

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Bibliographic Details
Published in:Plant molecular biology 1998-01, Vol.36 (1), p.1-10
Main Authors: Ibrahim, R K, Bruneau, A, Bantignies, B
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Conserved Sequence
DNA, Complementary
Methyltransferases - chemistry
Methyltransferases - classification
Methyltransferases - genetics
Phylogeny
Plants - classification
Plants - enzymology
Plants - genetics
Sequence Alignment
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Summary:Comparative analysis of the predicted amino acid sequences of a number of plant O-methyltransferase cDNA clones show that they share some 32-71% sequence identity, and can be grouped according to the different compounds they utilise as substrates. Five highly conserved regions are proposed as a signature for plant O-methyltransferases, two of which (regions I and IV) are believed to be involved in S-adenosyl-L-methionine and metal binding, respectively. The glycine-rich signature regions include a 36 amino acid domain which is located in the mid-terminal section of the carboxy terminus of most O-methyltransferase sequences. Cladistic analysis of the amino acid sequences suggests that plant O-methyltransferases may have arisen from common ancestral genes that were driven by different structural and/or functional requirements, and whose descendants segregated into different biochemical species. A comprehensive classification of plant O-methyltransferases is proposed following the guidelines of the Commission of Plant Gene Nomenclature.
ISSN:0167-4412
1573-5028
DOI:10.1023/A:1005939803300