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Induction of asymmetry into homodimers
The self‐regulation of biological signalling receptors via homodimerization is discussed in relation to the symmetry changes occurring when these receptors bind their target ligand. The idea of positive and negative cooperativity between dimerization and ligand binding, mediated by changes in the sy...
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| Published in: | Chirality (New York, N.Y.) N.Y.), 1998, Vol.10 (1-2), p.14-23 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3464-75597d78072cf87690e383d3cb4e8885c2ba811f1d7c4a43b33bf27b98aa22723 |
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| cites | cdi_FETCH-LOGICAL-c3464-75597d78072cf87690e383d3cb4e8885c2ba811f1d7c4a43b33bf27b98aa22723 |
| container_end_page | 23 |
| container_issue | 1-2 |
| container_start_page | 14 |
| container_title | Chirality (New York, N.Y.) |
| container_volume | 10 |
| creator | Bardsley, Ben Cho, Younghoon R. Westwell, Martin S. Williams, Dudley H. |
| description | The self‐regulation of biological signalling receptors via homodimerization is discussed in relation to the symmetry changes occurring when these receptors bind their target ligand. The idea of positive and negative cooperativity between dimerization and ligand binding, mediated by changes in the symmetry of the system, as a source of signalling control is considered; and an analogy made with the homodimerization of a glycopeptide antibiotic, ristocetin A, which displays negative cooperativity. Finally, the regulation of the bacterial aspartate receptor and the human growth hormone receptor is discussed as a function of ligand‐induced asymmetry. Chirality 10:14–23, 1998. © 1998 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/chir.4 |
| format | article |
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Chirality 10:14–23, 1998. © 1998 Wiley‐Liss, Inc.</description><identifier>ISSN: 0899-0042</identifier><identifier>EISSN: 1520-636X</identifier><identifier>DOI: 10.1002/chir.4</identifier><identifier>PMID: 9470206</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; asymmetry ; biological signalling ; cooperativity ; Dimerization ; Humans ; Protein Binding ; Receptors, Cell Surface - chemistry ; Receptors, Cell Surface - physiology ; Ristocetin - chemistry ; Ristocetin - metabolism ; ristocetin A</subject><ispartof>Chirality (New York, N.Y.), 1998, Vol.10 (1-2), p.14-23</ispartof><rights>Copyright © 1998 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3464-75597d78072cf87690e383d3cb4e8885c2ba811f1d7c4a43b33bf27b98aa22723</citedby><cites>FETCH-LOGICAL-c3464-75597d78072cf87690e383d3cb4e8885c2ba811f1d7c4a43b33bf27b98aa22723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchir.4$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchir.4$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,4043,27956,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9470206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bardsley, Ben</creatorcontrib><creatorcontrib>Cho, Younghoon R.</creatorcontrib><creatorcontrib>Westwell, Martin S.</creatorcontrib><creatorcontrib>Williams, Dudley H.</creatorcontrib><title>Induction of asymmetry into homodimers</title><title>Chirality (New York, N.Y.)</title><addtitle>Chirality</addtitle><description>The self‐regulation of biological signalling receptors via homodimerization is discussed in relation to the symmetry changes occurring when these receptors bind their target ligand. 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Chirality 10:14–23, 1998. © 1998 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>asymmetry</subject><subject>biological signalling</subject><subject>cooperativity</subject><subject>Dimerization</subject><subject>Humans</subject><subject>Protein Binding</subject><subject>Receptors, Cell Surface - chemistry</subject><subject>Receptors, Cell Surface - physiology</subject><subject>Ristocetin - chemistry</subject><subject>Ristocetin - metabolism</subject><subject>ristocetin A</subject><issn>0899-0042</issn><issn>1520-636X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LwzAAhoMoc079B0JPAw-daZLm46jDfcBUGH7dQpqmLNo2M2nR_ns3NubJ03t4H57DA8BlAkcJhOhGr6wfkSPQT1IEY4rp-zHoQy5EDCFBp-AshA8IoaCY9EBPEAYRpH0wnNd5qxvr6sgVkQpdVZnGd5GtGxetXOVyWxkfzsFJocpgLvY7AC-T--fxLF48Tefj20WsMaEkZmkqWM44ZEgXnFEBDeY4xzojhnOeapQpniRFkjNNFMEZxlmBWCa4UggxhAdguPOuvftqTWhkZYM2Zalq49ogmaCcCSL-QO1dCN4Ucu1tpXwnEyi3QeQ2iCQb8GpvbLPK5AdsX2DzX-_-b1ua7h-LHM_my60r3rE2NObnwCr_KSnDLJVvj1PJH8grg3dLOcG_ao52ow</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Bardsley, Ben</creator><creator>Cho, Younghoon R.</creator><creator>Westwell, Martin S.</creator><creator>Williams, Dudley H.</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Induction of asymmetry into homodimers</title><author>Bardsley, Ben ; Cho, Younghoon R. ; Westwell, Martin S. ; Williams, Dudley H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3464-75597d78072cf87690e383d3cb4e8885c2ba811f1d7c4a43b33bf27b98aa22723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>asymmetry</topic><topic>biological signalling</topic><topic>cooperativity</topic><topic>Dimerization</topic><topic>Humans</topic><topic>Protein Binding</topic><topic>Receptors, Cell Surface - chemistry</topic><topic>Receptors, Cell Surface - physiology</topic><topic>Ristocetin - chemistry</topic><topic>Ristocetin - metabolism</topic><topic>ristocetin A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bardsley, Ben</creatorcontrib><creatorcontrib>Cho, Younghoon R.</creatorcontrib><creatorcontrib>Westwell, Martin S.</creatorcontrib><creatorcontrib>Williams, Dudley H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chirality (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bardsley, Ben</au><au>Cho, Younghoon R.</au><au>Westwell, Martin S.</au><au>Williams, Dudley H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of asymmetry into homodimers</atitle><jtitle>Chirality (New York, N.Y.)</jtitle><addtitle>Chirality</addtitle><date>1998</date><risdate>1998</risdate><volume>10</volume><issue>1-2</issue><spage>14</spage><epage>23</epage><pages>14-23</pages><issn>0899-0042</issn><eissn>1520-636X</eissn><notes>ark:/67375/WNG-8M4V70BR-F</notes><notes>istex:A772821A167FFA70451689D0F1F83A8BAA874E72</notes><notes>ArticleID:CHIR4</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>The self‐regulation of biological signalling receptors via homodimerization is discussed in relation to the symmetry changes occurring when these receptors bind their target ligand. 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| identifier | ISSN: 0899-0042 |
| ispartof | Chirality (New York, N.Y.), 1998, Vol.10 (1-2), p.14-23 |
| issn | 0899-0042 1520-636X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79687949 |
| source | Wiley Online Library |
| subjects | Animals asymmetry biological signalling cooperativity Dimerization Humans Protein Binding Receptors, Cell Surface - chemistry Receptors, Cell Surface - physiology Ristocetin - chemistry Ristocetin - metabolism ristocetin A |
| title | Induction of asymmetry into homodimers |
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