Induction of asymmetry into homodimers

The self‐regulation of biological signalling receptors via homodimerization is discussed in relation to the symmetry changes occurring when these receptors bind their target ligand. The idea of positive and negative cooperativity between dimerization and ligand binding, mediated by changes in the sy...

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Bibliographic Details
Published in:Chirality (New York, N.Y.) N.Y.), 1998, Vol.10 (1-2), p.14-23
Main Authors: Bardsley, Ben, Cho, Younghoon R., Westwell, Martin S., Williams, Dudley H.
Format: Article
Language:English
Subjects:
Animals
asymmetry
biological signalling
cooperativity
Dimerization
Humans
Protein Binding
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - physiology
Ristocetin - chemistry
Ristocetin - metabolism
ristocetin A
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Summary:The self‐regulation of biological signalling receptors via homodimerization is discussed in relation to the symmetry changes occurring when these receptors bind their target ligand. The idea of positive and negative cooperativity between dimerization and ligand binding, mediated by changes in the symmetry of the system, as a source of signalling control is considered; and an analogy made with the homodimerization of a glycopeptide antibiotic, ristocetin A, which displays negative cooperativity. Finally, the regulation of the bacterial aspartate receptor and the human growth hormone receptor is discussed as a function of ligand‐induced asymmetry. Chirality 10:14–23, 1998. © 1998 Wiley‐Liss, Inc.
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.4