Changes of Soluble CD16 Levels in Serum of HIV-Infected Patients: Correlation with Clinical and Biologic Prognostic Factors

The modulation of soluble CD16 titers in human immunodeficiency virus (HIV)-infected patients' serum, with an initial increase in Centers for Disease Control (CDC) clinical stage II and ill patients followedbya dramatic drop in patients with AIDS (CDC clinical stage IV), is reported. These chan...

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Bibliographic Details
Published in:The Journal of infectious diseases 1990-03, Vol.161 (3), p.430-435
Main Authors: Khayat, David, Soubrane, Claude, Andrieu, Jean Marie, Visonneau, Sophie, Erne, Denise, Tourani, Jean Marc, Beldjord, Kheira, Weil, Marise, Fernandez, Eric, Jacquillat, Claude
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS
AIDS/HIV
Antibodies
Antigens
Antigens, CD - analysis
Antigens, Differentiation - analysis
Antigens, Differentiation, T-Lymphocyte - analysis
CD3 Complex
Female
Flow Cytometry
Fluorescent Antibody Technique
HIV
HIV infections
HIV Infections - immunology
human immunodeficiency virus
Humans
Lymphocytes
Major Articles
Male
Middle Aged
Natural killer cells
Neutrophils
Prognosis
Receptors
Receptors, Antigen, T-Cell - analysis
Receptors, Fc - analysis
Receptors, IgG
T lymphocytes
T-Lymphocytes - immunology
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Summary:The modulation of soluble CD16 titers in human immunodeficiency virus (HIV)-infected patients' serum, with an initial increase in Centers for Disease Control (CDC) clinical stage II and ill patients followedbya dramatic drop in patients with AIDS (CDC clinical stage IV), is reported. These changes are statistically correlated with the CDC staging system, the number of CD4+ cells, the amount of p24 antigen in serum, and the anti-p24 antibody titers, indicating the potential value of soluble CD16 titer as an easily available serum marker of disease progression. To evaluate a possible link between this observation and the expression of membrane-associated CD16/FcRIII, flow cytometry immunofluorescence analysis was performed on peripheral blood lymphocytes from patients in three CDC stages; no specific changes in the number of natural killer cells expressing CD16+ antigens or in the total number of Leu19+ cells were found. However, there was a statistical correlation between the absolute number of T cells expressing CD16 antigens (CD3+/CD16+) and the modulated titers of soluble CD16 in HIV-infected serum.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/161.3.430