Inflammatory pseudotumor of the liver. Clinicopathologic study and review of the literature

Clinicopathologic analysis of nine patients with inflammatory pseudotumor of the liver was reported. The age of the patients varied from 22 to 83 years old, with a male to female ratio of 8 to 1. They complained of intermittent fever and abdominal pain, and laboratory data on admission suggested an...

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Bibliographic Details
Published in:Cancer 1990-04, Vol.65 (7), p.1583-1590
Main Authors: Horiuchi, Ryuzo, Uchida, Toshikazu, Kojima, Takashi, Shikata, Toshio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Hepatocellular - diagnosis
Diagnosis, Differential
Female
Fibroma - diagnosis
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver Abscess - diagnosis
Liver Neoplasms - diagnosis
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Middle Aged
Portal Vein - diagnostic imaging
Technetium
Tomography, X-Ray Computed
Tumors
Ultrasonography
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Summary:Clinicopathologic analysis of nine patients with inflammatory pseudotumor of the liver was reported. The age of the patients varied from 22 to 83 years old, with a male to female ratio of 8 to 1. They complained of intermittent fever and abdominal pain, and laboratory data on admission suggested an inflammatory process. The solitary or multiple, well‐defined space‐occupying lesions were displayed by recently advanced imaging techniques. Partial hepatectomy, laparotomy, needle biopsy, or autopsy was performed in all nine patients with diagnoses of hepatocellular carcinoma, metastatic liver tumor, or liver abscess. Histologically, these lesions were composed of dense hyalinized fibrosis and/or infiltrating inflammatory cells constituting large numbers of foamy histiocytes, lymphocytes, and plasma cells. Obliterating phlebitis of relatively large branches of the portal vein was found, thus providing a diagnostic clue to distinction from the primary hepatic cancer by imagings. Considering the clinicopathologic features and the patients' histories, in which four patients had been in the Southeast Asian countries or India, it is possible that infection of microorganisms through the portal vein could participate in these lesions as a cause. Two patients died of causes probably related to this lesion, indicating poor prognosis in some patients, in contrast to the generally fair prognosis of previously published cases.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19900401)65:7<1583::AID-CNCR2820650722>3.0.CO;2-L