FLT3 ligand administration inhibits tumor growth in murine melanoma and lymphoma

Successful treatment of melanoma and lymphoma may result from the induction of specific antitumor immunity. Dendritic cells (DCs) are powerful antigen-presenting cells and show a remarkable capacity to stimulate antigen-specific T-cell responses. Administration of FLT3 ligand (FL) results in a rever...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1998-02, Vol.58 (3), p.380-383
Main Authors: ESCHE, C, SUBBOTIN, V. M, MALISZEWSKI, C, LOTZE, M. T, SHURIN, M. R
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Dendritic Cells - drug effects
Dendritic Cells - immunology
Drug Screening Assays, Antitumor
Immunity, Cellular - drug effects
Immunologic Factors - pharmacology
Immunologic Factors - therapeutic use
Immunotherapy
Lymphoma, T-Cell - immunology
Lymphoma, T-Cell - therapy
Male
Medical sciences
Melanoma, Experimental - immunology
Melanoma, Experimental - therapy
Membrane Proteins - pharmacology
Membrane Proteins - therapeutic use
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Pharmacology. Drug treatments
Recombinant Proteins - pharmacology
Recombinant Proteins - therapeutic use
Skin Neoplasms - immunology
Skin Neoplasms - therapy
T-Lymphocytes - immunology
Tumor Cells, Cultured
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Summary:Successful treatment of melanoma and lymphoma may result from the induction of specific antitumor immunity. Dendritic cells (DCs) are powerful antigen-presenting cells and show a remarkable capacity to stimulate antigen-specific T-cell responses. Administration of FLT3 ligand (FL) results in a reversible accumulation of functionally active DCs in both lymphoid and nonlymphoid tissues. Therefore, we evaluated the possible antitumor effect of FL in murine melanoma (B16 and CL8-1) and lymphoma (EL-4) models. In all experiments, tumor growth was significantly inhibited by FL administration. Analysis by immunohistochemistry revealed an increase in the DC accumulation within B16 and EL-4 tumors after treatment with FL. No change was observed for CL8-1 melanoma. These data suggest a potential role for FL in the immunotherapy of malignant skin tumors and possible DC involvement in this effect.
ISSN:0008-5472
1538-7445