Leptin regulates proinflammatory immune responses

Obesity is associated with an increased incidence of infection, diabetes, and cardiovascular disease, which together account for most obesity-related morbidity and mortality. Decreased expression of leptin or of functional leptin receptors results in hyperphagia, decreased energy expenditure, and ob...

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Bibliographic Details
Published in:The FASEB journal 1998-01, Vol.12 (1), p.57-65
Main Authors: Loffreda, S. (John Hopkins University, Baltimore, MD.), Yang, S.Q, Lin, H.Z, Karp, C.L, Brengman, M.L, Wang, D.J, Klein, A.S, Bulkley, G.B, Bao, C, Noble, P.W
Format: Article
Language:English
Subjects:
Animals
Carrier Proteins - genetics
Carrier Proteins - metabolism
CITOQUINAS
CYTOKINE
CYTOKINES
Cytokines - biosynthesis
Cytokines - genetics
FAGOCITOS
Gene Expression Regulation
Inflammation - metabolism
Inflammation - physiopathology
Leptin
Lipopolysaccharides - pharmacology
MACROFAGOS
MACROPHAGE
MACROPHAGES
Macrophages - drug effects
Macrophages - immunology
Mice
Mice, Obese
OVERWEIGHT
PHAGOCYTE
PHAGOCYTES
PHAGOCYTOSIS
Phagocytosis - physiology
Proteins - physiology
Receptors, Cell Surface
Receptors, Leptin
Recombinant Proteins
SOBREPESO
SURPOIDS
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Summary:Obesity is associated with an increased incidence of infection, diabetes, and cardiovascular disease, which together account for most obesity-related morbidity and mortality. Decreased expression of leptin or of functional leptin receptors results in hyperphagia, decreased energy expenditure, and obesity. It is unclear, however, whether defective leptin-dependent signal transduction directly promotes any of the conditions that frequently complicate obesity. Abnormalities in tumor necrosis factor alpha expression have been noted in each of the above comorbid conditions, so leptin deficiency could promote these complications if leptin had immunoregulatory activity. Studies of rodents with genetic abnormalities in leptin or leptin receptors revealed obesity-related deficits in macrophage phagocytosis and the expression of proinflammatory cytokines both in vivo and in vitro. Exogenous leptin up-regulated both phagocytosis and the production of proinflammatory cytokines. These results identify an important and novel function for leptin: up-regulation of inflammatory immune responses, which may provide a common pathogenetic mechanism that contributes to several of the major complications of obesity.
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.12.1.57