Increased disorderliness and decreased mass and daily rate of endogenous growth hormone secretion in adult turner syndrome: the impact of body composition, maximal oxygen uptake and treatment with sex hormones

The objectives of this study were to (1) quantify pulsatility and orderliness of 24-h growth hormone (GH) secretion in adult Turner syndrome; (2) study the impact of sex steroid replacement therapy in adult Turner syndrome on these measures of GH secretion, and in addition examine the differential e...

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Bibliographic Details
Published in:Growth hormone & IGF research 1998-08, Vol.8 (4), p.289-298
Main Authors: Gravholt, Claus Højbjerg, Veldhuis, Johannes D., Christiansen, Jens Sandahl
Format: Article
Language:English
Subjects:
24-h GH secretion
Administration, Cutaneous
Administration, Oral
Adult
adults
approximate entropy
Body Composition - physiology
Case-Control Studies
deconvolution analysis
Estradiol - administration & dosage
Female
female sex hormone replacement
Gonadal Steroid Hormones - therapeutic use
Hormone Replacement Therapy
Human Growth Hormone - secretion
Humans
lean body mass
maximal oxygen uptake
Norethindrone - administration & dosage
Oxygen Consumption
Statistics, Nonparametric
Turner syndrome
Turner Syndrome - drug therapy
Turner Syndrome - metabolism
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Summary:The objectives of this study were to (1) quantify pulsatility and orderliness of 24-h growth hormone (GH) secretion in adult Turner syndrome; (2) study the impact of sex steroid replacement therapy in adult Turner syndrome on these measures of GH secretion, and in addition examine the differential effect of oral vs transdermal estrogen administration on GH secretion patterns. To these ends, we used deconvolution analysis and approximate entropy (ApEn) to quantify GH release over 24 h in 21 patients with Turner syndrome before and during sex hormone substitution, compared to an age-matched control group. Deconvolution analysis revealed that the mass of GH secreted per burst and production rate was significantly lower in Turner patients compared to controls, resulting in a significantly lower integrated 24-h GH concentration. However, multiple stepwise regression revealed that lean body mass (LBM) and maximal oxygen uptake were significant discriminative variable, explaining a large part of the variation in mass secreted per burst ( r=0.72, P
ISSN:1096-6374
1532-2238
DOI:10.1016/S1096-6374(98)80124-X