Expression of CD23 antigen and its ligands in children with intrinsic and extrinsic asthma

The role of the low‐affinity IgE receptor CD23 in immune reactions has been further emphasized by recent discoveries of novel surface ligands for CD23: CD21, CD11b, and CD11c. We previously observed the difference between the expression of CD23 and CD21 antigens in children suffering from extrinsic...

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Bibliographic Details
Published in:Allergy (Copenhagen) 1997-12, Vol.52 (12), p.1238-1242
Main Authors: Aberle, N., Gagro, A., Rabatić, S., Reiner‐Banovac, Ž., Dekaris, D.
Format: Article
Language:English
Subjects:
Adolescent
Allergic diseases
Antigens, CD20 - analysis
Asthma - etiology
Asthma - immunology
Biological and medical sciences
CD11b
CD11c
CD23
Child
Child, Preschool
extrinsic asthma
Female
Flow Cytometry
Humans
Immunopathology
Integrin alphaXbeta2 - analysis
intrinsic asthma
Macrophage-1 Antigen - analysis
Male
Medical sciences
Receptors, Complement 3d - analysis
Receptors, IgE - analysis
Respiratory and ent allergic diseases
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Summary:The role of the low‐affinity IgE receptor CD23 in immune reactions has been further emphasized by recent discoveries of novel surface ligands for CD23: CD21, CD11b, and CD11c. We previously observed the difference between the expression of CD23 and CD21 antigens in children suffering from extrinsic asthma when compared to healthy controls. In the present study, we investigated the expression of CD23 and its ligand CD21 on CD20+B cells in 44 asthmatic children (23 allergic and 21 nonallergic) using three‐color immunofluorescence analysis. In addition, the expression of two other ligands for CD23, CD11b, and CD11c, on T cells (CD3+), a subpopulation of T cells (CD4+ and CD8+), natural killer cells (CD56+), and monocytes (CD14+) was tested by two‐color immunofluorescence analysis in 12 allergic and 14 nonallergic children. We found that children with extrinsic asthma had higher levels of CD23+ B cells than those with intrinsic asthma. No difference was observed in the percentage of either CD23+CD21+ or CD23‐ CD21+ B cells. The CD11b antigen was expressed on each tested population, but only on CD4+ T cells was CD11b significantly increased in children with extrinsic asthma. CD11c was expressed mainly on monocytes, and no difference was observed between tested groups. The increased percentage of CD11b antigen on CD4+ T cells and the increased percentage of CD23 antigen on B cells in children with extrinsic asthma provide further evidence of the immunologic differences between intrinsic and extrinsic asthma.
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.1997.tb02530.x