Spontaneous anaplastic large cell lymphoma in a chimpanzee: A clinicopathological and immunohistochemical study

: An anaplastic large cell lymphoma with disseminated abdominal metastases was diagnosed in a 35‐year‐old male chimpanzee. Clinically, the animal displayed lethargy, weight loss, ascites, and abdominal distention. Imaging studies showed several large abdominal masses. At necropsy, variably sized mas...

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Bibliographic Details
Published in:Journal of medical primatology 1997-10, Vol.26 (5), p.260-266
Main Authors: Binhazim, A.A., Lee, D.R., Bernacky, B.J., Rizvi, T.A.
Format: Article
Language:English
Subjects:
Abdomen
abdominal
Animals
Antigens, CD20 - analysis
Ape Diseases - immunology
Ape Diseases - pathology
Ape Diseases - virology
CD3
CD3 Complex - analysis
CD30
Immunohistochemistry
Ki-1 Antigen - analysis
lymphoid
Lymphoma, Large-Cell, Anaplastic - immunology
Lymphoma, Large-Cell, Anaplastic - pathology
Lymphoma, Large-Cell, Anaplastic - veterinary
Male
neoplasia
Non-Hodgkin's lymphoma
Pan troglodytes
Retroviridae - isolation & purification
T-cell
tumor
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Summary:: An anaplastic large cell lymphoma with disseminated abdominal metastases was diagnosed in a 35‐year‐old male chimpanzee. Clinically, the animal displayed lethargy, weight loss, ascites, and abdominal distention. Imaging studies showed several large abdominal masses. At necropsy, variably sized masses of neoplastic mesenteric lymph nodes that encompassed several intestinal loops were present throughout the abdomen. The largest mass measured 9 × 5 cm and had cauliflower‐like protrusions into the jejunal lumen. The entire abdominal cavity was covered by a sheet of neoplastic tissue. Histopathologically, the tumor consisted of solid sheets of proliferating lymphoid cells forming a cohesive growth that filled the lymph node sinuses. The tumor had invaded the intestinal wall. Anaplastic large cell lymphoma was diagnosed from immunohistochemistry findings on the basis of positive reaction to the CD3 and CD30 markers and negative reaction to the CD20 marker. Serologic analysis revealed positive titers for Epstein‐Barr, cytomegalo‐, and varicella‐zoster viruses. Both serologic and virologic studies showed no evidence of detectable retroviral infection. This type of tumor has not been reported before in the chimpanzee.
ISSN:0047-2565
1600-0684
DOI:10.1111/j.1600-0684.1997.tb00221.x