Threshold of metabolic acidosis associated with newborn complications

OBJECTIVE: Our purpose was to determine the threshold of metabolic acidosis at delivery associated with newborn complications. STUDY DESIGN: This study was a matched case-control study of 174 term newborn infants. Three groups defined by umbilical artery base deficit at birth were 4 to 8 mmol/L, 8 t...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 1997-12, Vol.177 (6), p.1391-1394
Main Authors: Low, James A., Lindsay, Brian G., Derrick, E.Jane
Format: Article
Language:English
Subjects:
Acidosis - blood
Acidosis - complications
Biological and medical sciences
Case-Control Studies
Delivery, Obstetric
Delivery. Postpartum. Lactation
Differential Threshold
Disorders
Female
Fetal metabolic acidosis
Fetus - metabolism
Gynecology. Andrology. Obstetrics
Humans
Incidence
Infant, Newborn
Infant, Newborn, Diseases - epidemiology
Infant, Newborn, Diseases - etiology
Medical sciences
newborn complications
Obstetric Labor Complications
Pregnancy
Pregnancy Complications
Umbilical Arteries
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Summary:OBJECTIVE: Our purpose was to determine the threshold of metabolic acidosis at delivery associated with newborn complications. STUDY DESIGN: This study was a matched case-control study of 174 term newborn infants. Three groups defined by umbilical artery base deficit at birth were 4 to 8 mmol/L, 8 to 12 mmol/L, and 12 to 16 mmol/L. Newborn complications during the 5 days after birth were documented. A composite complication score defined the magnitude of all complications in each neonate. RESULTS: Moderate and severe newborn encephalopathy and respiratory complications and composite complication scores >3 were increased in the group with an umbilical artery base deficit of 12 to 16 mmol/L. Moderate or severe newborn complications occurred in 10% of newborns in the same group, whereas such complications occur in 40% of neonates with an umbilical artery base deficit >16 mmol/L at birth. CONCLUSION: The threshold of fetal metabolic acidosis at delivery when moderate or severe newborn complications may occur is in an umbilical artery base deficit of 12 mmol/L. Thereafter, increasing metabolic acidosis is associated with a progression of severity of newborn complications.(Am J Obstet Gynecol 1997;177:4)
ISSN:0002-9378
1097-6868
DOI:10.1016/S0002-9378(97)70080-2