Developmental Changes in UDP-N-Acetylglucosamine 2-Epimerase Activity of Rat and Guinea-Pig Liver

The activity of UDP-N-acetylglucosamine 2-epimerase was determined in the liver of rats and guinea-pigs of different ages. The activity of this enzyme in rats was low at birth, increased to a maximum value on day 15, and fell gradually until day 30. Thereafter, it increased up to the 60th day. The a...

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Bibliographic Details
Published in:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 1997-09, Vol.118 (1), p.13-15
Main Authors: Gal, Beatriz, Ruano, Marı́a-José, Puente, Ricardo, Garcı́a-Pardo, Luis A, Rueda, Ricardo, Gil, Angel, Hueso, Pablo
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Carbohydrate Epimerases - metabolism
development
Escherichia coli Proteins
Female
Guinea Pigs
Guinea-pig
liver
Liver - enzymology
Liver - growth & development
Liver - metabolism
Male
Milk - metabolism
N-Acetylneuraminic Acid - metabolism
Neuraminic Acids - metabolism
rat
Rats
Rats, Wistar
sialic acid
Species Specificity
UDP-N-acetylglucosamine 2-epimerase
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Summary:The activity of UDP-N-acetylglucosamine 2-epimerase was determined in the liver of rats and guinea-pigs of different ages. The activity of this enzyme in rats was low at birth, increased to a maximum value on day 15, and fell gradually until day 30. Thereafter, it increased up to the 60th day. The activity profile of the enzyme from guinea-pig liver was very similar. However, guinea-pig activity was 2–5 times lower than in rats. Both rats and guinea-pigs displayed similar liver sialic acid contents which increased from birth to 2 months of age. Rats also showed a N-glycolylneuraminic acid content that decreased from birth to 2 months. From these results we can inferred that postnatal UDP-N-acetylglucosamine 2-epimerase activity seems to be correlated with age and the developmental states of rats and guinea-pigs.
ISSN:1096-4959
1879-1107
DOI:10.1016/S0305-0491(97)00016-3