Low plasma vitamins E and C: increased risk of angina in Scottish men

Cross-cultural studies suggest that low plasma antioxidant levels contribute to the high incidence of coronary heart disease (CHD) in Scotland. One hundred twenty-five cases of angina without reported history were identified by a postal WHO chest pain questionnaire from a systemic population sample...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1989, Vol.570 (1), p.291-295
Main Authors: Riemersma, R.A. (University of Edinburgh, Edinburgh, Scotland), Wood, D.A, MacIntyre, C.C.A, Elton, R, Gey, K.F, Oliver, M.F
Format: Article
Language:English
Subjects:
ACIDE ASCORBIQUE
ACIDO ASCORBICO
Adult
ADULTE
ADULTOS
ADULTS
Angina Pectoris - blood
ASCORBIC ACID
Ascorbic Acid - blood
CARENCE EN VITAMINES
Case-Control Studies
CIRCULATORY DISORDERS
DEFICIENCIA DE VITAMINAS
DOLOR
DOULEUR
ECOSSE
ESCOCIA
HOMBRES
HOMME
Humans
Male
MEN
Middle Aged
PAIN
Risk Factors
SCOTLAND
THORAX
TOCOFEROLES
TOCOPHEROL
TOCOPHEROLS
TORAX
TRASTORNOS CIRCULATORIOS
TROUBLE CIRCULATOIRE
VITAMIN DEFICIENCIES
Vitamin E - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cross-cultural studies suggest that low plasma antioxidant levels contribute to the high incidence of coronary heart disease (CHD) in Scotland. One hundred twenty-five cases of angina without reported history were identified by a postal WHO chest pain questionnaire from a systemic population sample of 6000 Edinburgh men (35-54 years). Classical CHD risk factors (lipids, blood pressure, smoking, and relative weight), plasma vitamins, and a new independent CHD risk factor, adipose tissue linoleate, were measured in angina (n = 125) and healthy controls (n = 430). Cigarette smoking was common in angina (46% vs. 29%, p less than 0.01), and adipose tissue linoleate was lower (8.77 +/- 0.18% vs. 9.81 +/- 0.14% (p less than 0.01). Classical CHD risk factors were not different. Vitamin E/cholesterol molar ratio (micron/mM) was lower in angina than in controls: 1.58 +/- 0.03 vs. 1.66 +/- 0.02 (p less than 0.01). Plasma vitamin C was also lower in angina than in controls: 23.6 +/- 1.7 vs. 30.5 +/- 1.1 microM (p less than 0.001). The relative risk of angina for those in the lowest versus those in the highest quintile of the vitamin E/cholesterol ratio distribution was 2.2:1, irrespective of other risk factors (p less than 0.009). Adipose tissue linoleate removed the association between vitamin E and angina. The relative risk of angina for those in the lowest versus those in the highest quintile of plasma vitamin C was 2.6:1 (p less than 0.01), and the increased risk was also independent of classical risk factors, but closely related to a smoking habit. Low plasma vitamin E or adipose linoleate predisposes to angina, and smoking may increase the risk of angina by lowering plasma vitamin C levels in Scottish men.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1989.tb14928.x