Colonic endocrine cells in inflammatory bowel disease

El‐Salhy M, Danielsson Å, Stenling R, Grimelius L (University Hospital, Umeå; and University Hospital, Uppsala; Sweden). Colonic endocrine cells in inflammatory bowel disease. J Intern Med 1997; 242: 413–19. Objectives To study colonic endocrine cell types in patients with ulcerative colitis (UC) an...

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Published in:Journal of internal medicine 1997-11, Vol.242 (5), p.413-419
Main Authors: El‐Salhy, M., Danielsson, Å., Stenling, R., Grimelius, L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Colitis, Ulcerative - pathology
Colon - pathology
computer image analysis
Crohn Disease - pathology
Crohn's disease
Enteroendocrine Cells - pathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Inflammatory Bowel Diseases - pathology
Male
Medical sciences
Middle Aged
Other diseases. Semiology
pancreatic polypeptide
polypeptide YY
serotonin
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
ulcerative colitis
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Summary:El‐Salhy M, Danielsson Å, Stenling R, Grimelius L (University Hospital, Umeå; and University Hospital, Uppsala; Sweden). Colonic endocrine cells in inflammatory bowel disease. J Intern Med 1997; 242: 413–19. Objectives To study colonic endocrine cell types in patients with ulcerative colitis (UC) and Crohn's disease (CD). Setting Departments of Medicine and Pathology, University Hospitals, Umeå and Uppsala, Sweden. Subjects Seventeen patients with UC (seven females and 10 males) and 11 patients with CD (five females and six males). Twenty‐two patients (eight females and 14 males) operated on for colon carcinoma and without signs of inflammatory bowel disease were used as controls. Measurements The colonic endocrine cell types were identified by immunohistochemical methods and quantified by computed image analysis. Results The areas of the argyrophil cells as well as those immunoreactive to chromogranin A and serotonin were significantly increased in patients with both UC and CD, compared with those in the controls. In patients with CD, the areas of polypeptide YY(PYY)‐ and pancreatic polypeptide (PP)‐immunoreactive cells were significantly reduced, whilst the area of enteroglucagon‐immunoreactive cells was increased. There was no statistical difference in endocrine cell area between specimens with slight versus severe inflammation, except for PYY and enteroglucagon cell areas in patients with CD. Whilst the former cell area decreased, the latter increased in specimens with severe inflammation. The mean cellular area for each endocrine cell type did not differ between the controls and patients with UC or CD. Conclusions The increase in the serotonin‐immunoreactive cell area in patients with both UC and CD might be one of the factors causing reduced colonic contraction and increased intraluminal pressure observed in patients with inflammatory bowel disease. Furthermore, in patients with CD, the decreased PYY‐immunoreactive cell area may explain the decreased absorption and increased secretion found in these patients.
ISSN:0954-6820
1365-2796
DOI:10.1046/j.1365-2796.1997.00237.x