Effects of milk-borne colony stimulating factor-1 on circulating growth factor levels in the newborn infant

Colony stimulating factor-1 (CSF-1) concentrations in colostrum were 20 to 25 times higher than in serum at birth and declined with lactation. No difference in concentrations of circulating CSF-1, however, were noted between breast-fed and formula-fed infants, suggesting that milk-borne CSF-1 may fe...

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Bibliographic Details
Published in:The Journal of pediatrics 1997-11, Vol.131 (5), p.748-750
Main Authors: Flidel-Rimon, Orna, Roth, Philip
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Female
Food, Formulated
Fundamental and applied biological sciences. Psychology
Gestational Age
Growth Substances - blood
Hormone metabolism and regulation
Humans
Infant Nutritional Physiological Phenomena
Infant, Newborn
Macrophage Colony-Stimulating Factor - blood
Male
Milk, Human - chemistry
Pregnancy. Parturition. Lactation
Radioimmunoassay
Vertebrates: reproduction
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Summary:Colony stimulating factor-1 (CSF-1) concentrations in colostrum were 20 to 25 times higher than in serum at birth and declined with lactation. No difference in concentrations of circulating CSF-1, however, were noted between breast-fed and formula-fed infants, suggesting that milk-borne CSF-1 may feed back negatively on endogenous growth factor levels, may act locally in the gastrointestinal tract, or may be locally degraded. (J Pediatr 1997;131:748-50)
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(97)70105-7