Rat GluR7 and a Carboxy-Terminal Splice Variant, GluR7b, Are Functional Kainate Receptor Subunits with a Low Sensitivity to Glutamate

Glutamate receptors of the kainate-preferring subtype have recently been shown to mediate synaptic transmission in the hippocampus. The low-affinity kainate receptor subunit GluR7 was found to be nonfunctional in previous studies. We report here that the GluR7 subunit and a novel carboxy-terminal sp...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 1997-11, Vol.19 (5), p.1141-1146
Main Authors: Schiffer, Hans H, Swanson, Geoffrey T, Heinemann, Stephen F
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
DNA, Recombinant
Genetic Variation - physiology
GluK3 Kainate Receptor
Glutamic Acid - pharmacology
Molecular Sequence Data
Rats
Receptors, Kainic Acid - drug effects
Receptors, Kainic Acid - genetics
Receptors, Kainic Acid - metabolism
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Summary:Glutamate receptors of the kainate-preferring subtype have recently been shown to mediate synaptic transmission in the hippocampus. The low-affinity kainate receptor subunit GluR7 was found to be nonfunctional in previous studies. We report here that the GluR7 subunit and a novel carboxy-terminal splice variant, GluR7b, are functional glutamate receptors with unique pharmacological properties. In particular, glutamate exhibits a 10-fold lower potency for (non-desensitized) GluR7-mediated currents as compared to other non-NMDA receptor channels. These data will facilitate understanding of the distinct role played by GluR7 receptors in synaptic transmission.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(00)80404-3