PHARMACOKINETIC AND CLINICAL STUDIES ON CEFMENOXIME IN NEONATES AND PREMATURE INFANTS

Cefmenoxime (CMX) was administered by intravenous bolus injection to a total of 23neonates and premature babies with ages of 1 to 26 days at a dose of 10 or 20mg/kg and their plasma and urine concentrations and urinary recovery rates were determined up to 6 hours after administration. In addition, f...

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Published in:Japanese journal of antibiotics 1989/12/25, Vol.42(12), pp.2672-2691
Main Authors: MOTOHIRO, TAKASHI, KAWAKAMI, AKIRA, TANAKA, KOICHI, KOGA, TATSUHIKO, SHIMADA, YASUSHI, TOMITA, SHOBUN, SAKATA, YASUTAKA, FUJIMOTO, TAMOTSU, NISHIYAMA, TOHRU, KUDA, NAOKI, TOMINAGA, KAORU, YAMASHITA, FUMIO, KIMURA, KEN, ICHIKAWA, KOTARO, NAKAO, MITSUYOSHI, MATSUMOTO, TOHRU, ODA, KEIKO, HARA, KIMIKO, ANDO, HIROSHI, ICHIKAWA, NORIKO, HIROSE, FUJIKO, OHTAKI, ETSUO, YAMASHITA, YUJI, TAKAJO, NOBUHIKO, HASHIMOTO, NOBUO, FUJISAWA, TAKUJI, KINOSHITA, SHOHEI, NAKANO, MITSURO, IMAI, SHOICHI, NAGAYAMA, KIYOTAKA, TAKEISHI, SUGURU, TANAKA, NOBUO, SAKAMOTO, HIROFUMI, ISHIKAWA, YUTAKA, ARAKI, HISAAKI, TANAKA, YOSHIMI, TSUGAWA, SHIN, YUASA, TAKESHI, IRIKI, TSUKASA, HARADA, MOTOHIKO, HASHIMOTO, TAKEO, SATO, NOBORU, YAMASHITA, YUSHIRO, NISHIMI, TOSHIHIRO, EGUCHI, HARUHIKO, DAI, SHUNICHI, TSUNOSUE, MIWAKO, FUKUDA, SEIICHI, NAKASHIMA, HIROFUMI, HARADA, YUTAKA, ISHIMOTO, KOJI, MATSUYUKI, MASAKADO, KUBOTA, KAORU, OHTA, MASANORI, MOROI, TOSHIHIRO, MATSUO, HIROSHI, KAJIYAMA, JUNKO, HORIKAWA, MIZUHO, TANAKA, EIICHIRO, URABE, DAISAKU, YUGE, KEN
Format: Article
Language:Japanese
Subjects:
Bacterial Infections - drug therapy
Bacterial Infections - prevention & control
Cefmenoxime - pharmacokinetics
Cefmenoxime - therapeutic use
Drug Evaluation
Female
Humans
Infant, Newborn - metabolism
Infant, Premature - metabolism
Infant, Premature, Diseases - drug therapy
Infant, Premature, Diseases - prevention & control
Male
Maxillary Sinusitis - drug therapy
Pneumonia - drug therapy
Sepsis - drug therapy
Urinary Tract Infections - drug therapy
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Summary:Cefmenoxime (CMX) was administered by intravenous bolus injection to a total of 23neonates and premature babies with ages of 1 to 26 days at a dose of 10 or 20mg/kg and their plasma and urine concentrations and urinary recovery rates were determined up to 6 hours after administration. In addition, for the treatment of bacterial infections, diagnosed or suspected, or for the prophylaxis of bacterial infections, the drug was administered to a total of 27 neonates, premature babies and infants, with ages of 0 day to 3 months. It was possible to evaluate therapeutic efficacy and prophylactic efficacy in 15 cases and 7 cases, respectively. In these cases, side effects and bacteriological effects and, in some of them, changes in laboratory test values were also investigated. The obtained results are summarized below. 1. At a dosage level of 10mg/kg (n=7), peak plasma concentrations at 5 minutes after administration, were 42.6μg/ml in neonates with ages of 15 to 21 days and 45.9μg/ml in those with ages of 22 to 28 days in a group of
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.42.2672