Influence of naloxone on the cellular immune response to head-up tilt in humans

To evaluate a possible role for beta-endorphin in the stress-induced modulation of natural killer (NK) cells, immunologically competent blood cells were followed in eight male volunteers administered either Naloxone or saline (control) during head-up tilt maintained until the appearance of presyncop...

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Bibliographic Details
Published in:European journal of applied physiology 1997-11, Vol.76 (5), p.415-420
Main Authors: KLOKKER, M, SECHER, N. H, MADSEN, P, OLESEN, H. L, MATZEN, S, KNIGGE, U, WARBERG, J, PEDERSEN, B. K
Format: Article
Language:English
Subjects:
Adult
Antigens, Surface - analysis
Applied physiology
Biological and medical sciences
Catecholamines - blood
Flow Cytometry
Hormones - blood
Human physiology applied to population studies and life conditions. Human ecophysiology
Humans
Immunity, Cellular - drug effects
Immunity, Cellular - immunology
Immunity, Cellular - physiology
Killer Cells, Natural - drug effects
Killer Cells, Natural - physiology
Leukocyte Count - drug effects
Male
Medical sciences
Monocytes - drug effects
Monocytes - physiology
Naloxone - pharmacology
Narcotic Antagonists - pharmacology
Posture - physiology
Space life sciences
Tilt-Table Test
Transports. Aerospace. Diving. Altitude
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Summary:To evaluate a possible role for beta-endorphin in the stress-induced modulation of natural killer (NK) cells, immunologically competent blood cells were followed in eight male volunteers administered either Naloxone or saline (control) during head-up tilt maintained until the appearance of presyncopal symptoms (PS). The PS appeared more rapidly with Naloxone compared to control [5.7 (SEM 1.1) vs 22.3 (SEM 5.1) min; P = 0.01]. The NK cell activity increased threefold during PS partly due to an increase in CD16+ and CD56+ NK cells in blood. In support, NK cell activity boosted with interferon-alpha and interleukin 2 rose in parallel with unboosted NK cell activity and NK cell concentration and activities returned to the baseline level after 105 min. The total lymphocyte count and the concentrations of CD3+, CD4+, CD8+, CD16+, and CD56+ cells increased during PS. Head-up tilt also induced an increase in plasma adrenaline concentration during control PS and a rise in plasma cortisol and adrenocorticotropic hormone concentrations up to 30 min thereafter, whereas no significant changes were found in plasma concentrations of noradrenaline, growth hormone, or beta-endorphin. The results would indicate an influence of endorphin on the increase in plasma adrenaline concentration during head-up tilt and at the same time contra-indicate a significant role for adrenaline in the provocation of PS. The influence of head-up tilt on plasma beta-endorphin was too small to influence the modulation of the cellular immune system.
ISSN:0301-5548
1439-6319
1432-1025
1439-6327
DOI:10.1007/s004210050270