Antimycins, Inhibitors of ATP-Citrate Lyase, from a Streptomyces sp

A related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species. The group includes known antimycins A1, A2, A3 and A4, and new antimycins A7 and A8. These compounds inhibit ATP-citrate lyase with Ki values of 4 to 60 μM agai...

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Bibliographic Details
Published in:Journal of antibiotics 1997/09/25, Vol.50(9), pp.729-733
Main Authors: BARROW, COLIN J., OLEYNEK, JOSEPH J., MARINELLI, VINCENT, SUN, HAO H., KAPLITA, PAUL, SEDLOCK, DAVID M., GILLUM, AMANDA M., CHADWICK, CHRISTOPHER C., COOPER, RAYMOND
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antimycin A - analogs & derivatives
Applied microbiology
ATP Citrate (pro-S)-Lyase - antagonists & inhibitors
Biological and medical sciences
Fermentation
Fundamental and applied biological sciences. Psychology
Microbiology
Molecular Structure
Streptomyces
Structure-Activity Relationship
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Summary:A related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species. The group includes known antimycins A1, A2, A3 and A4, and new antimycins A7 and A8. These compounds inhibit ATP-citrate lyase with Ki values of 4 to 60 μM against the substrate magnesium citrate. The structures of the new antimycins were determined by spectroscopic analyses.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.50.729