Does cytomegalovirus cause glomerular injury in renal allograft recipients?

The case of a 16-yr-old woman who received an ABO-incompatible renal allograft for end-stage renal disease due to membranoproliferative glomerulonephritis type I is presented. The patient's posttransplant course was complicated by cytomegalovirus (CMV) infection and the rare finding of glomerul...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 1997-11, Vol.8 (11), p.1801-1808
Main Authors: BIRK, P. E, CHAVERS, B. M
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Cytomegalovirus - immunology
Cytomegalovirus Infections - diagnosis
Cytomegalovirus Infections - epidemiology
Cytomegalovirus Infections - etiology
Cytomegalovirus Infections - therapy
Female
Glomerulonephritis, Membranoproliferative - complications
Humans
Immunotherapy
Incidence
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - surgery
Kidney Glomerulus - pathology
Kidney Glomerulus - virology
Kidney Transplantation - adverse effects
Medical sciences
Risk Factors
Serologic Tests
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Transplantation, Homologous - adverse effects
Viral Vaccines - administration & dosage
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Description
Summary:The case of a 16-yr-old woman who received an ABO-incompatible renal allograft for end-stage renal disease due to membranoproliferative glomerulonephritis type I is presented. The patient's posttransplant course was complicated by cytomegalovirus (CMV) infection and the rare finding of glomerular CMV inclusions on renal biopsy. This article focuses on the pathology and pathogenesis of glomerular injury associated with CMV infection in renal allograft recipients and also reviews the epidemiology, clinical implications, diagnosis and management of CMV infection in these patients.
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.V8111801