Partial transformation from fast to slow muscle fibers induced by deafferentation of capsaicin-sensitive muscle afferents

Mechanical and histochemical characteristics of the lateral gastrocnemius (LG) muscle of the rat were examined 21 days after capsaicin injection into the LG muscle. The capsaicin caused a decrease in generation rate of twitch and tetanic tension and an increase in fatigue resistance of LG muscle. Th...

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Bibliographic Details
Published in:Muscle & nerve 1997-11, Vol.20 (11), p.1404-1413
Main Authors: Brunetti, Orazio, Barazzoni, Anna M., Della Torre, Giovannella, Clavenzani, Paolo, Pettorossi, Vito E., Bortolami, Ruggero
Format: Article
Language:English
Subjects:
Afferent Pathways - physiology
Animals
Biological and medical sciences
capsaicin
Capsaicin - pharmacology
Denervation
Fundamental and applied biological sciences. Psychology
group III and IV muscle afferents
Hindlimb
Histocytochemistry
Injections
Male
muscle fiber trophism
Muscle Fibers, Fast-Twitch - physiology
Muscle Fibers, Slow-Twitch - physiology
Muscles - drug effects
Muscles - innervation
Muscles - physiology
neurokinins
Neurons, Afferent - drug effects
Neurons, Afferent - physiology
Rats
Rats, Wistar
Space life sciences
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:Mechanical and histochemical characteristics of the lateral gastrocnemius (LG) muscle of the rat were examined 21 days after capsaicin injection into the LG muscle. The capsaicin caused a decrease in generation rate of twitch and tetanic tension and an increase in fatigue resistance of LG muscle. The histochemical muscle fiber profile evaluated by myosin adenosine triphosphatase and reduced nicotinamide adenine dinucleotide tetrazolium reductase methods showed an increase of type I and IIC fibers and a decrease of the type IIB in whole muscle, and a decrease of the IIA, IIX fibers in the red part accompanied by their increase in the white part. Therefore the capsaicin treatment, which selectively eliminated fibers belonging to the III and IV groups of muscle afferents, induced muscle fiber transformation from fast contracting fatiguing fibers to slowly contracting nonfatiguing ones. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1404–1413, 1997
ISSN:0148-639X
1097-4598
DOI:10.1002/(SICI)1097-4598(199711)20:11<1404::AID-MUS8>3.0.CO;2-E