Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway

A mechanism by which members of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory factor cytokine family regulate gliogenesis in the developing mammalian central nervous system was characterized. Activation of the CNTF receptor promoted differentiation of cerebral cortical precursor cells i...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1997-10, Vol.278 (5337), p.477-483
Main Authors: Bonni, Azad, Sun, Yi, Nadal-Vicens, Mireya, Bhatt, Ami, Frank, David A., Rozovsky, Irina, Stahl, Neil, Yancopoulos, George D., Greenberg, Michael E.
Format: Article
Language:English
Subjects:
Anatomy
Animals
Antibodies
Antigens, CD - metabolism
Astrocytes
Astrocytes - cytology
Astrocytes - drug effects
Astrocytes - metabolism
Biological and medical sciences
Cell Differentiation
Cell Division
Cell Lineage
Cells, Cultured
Cellular biology
Cellular differentiation
Cerebral Cortex - cytology
Cerebral Cortex - embryology
Cilia
Cilia and ciliary motion
Ciliary Neurotrophic Factor
Cultured cells
Cytokine Receptor gp130
Cytokines
Dimerization
DNA-Binding Proteins - metabolism
Embryology: invertebrates and vertebrates. Teratology
Fundamental and applied biological sciences. Psychology
Glial Fibrillary Acidic Protein - biosynthesis
Growth Inhibitors - metabolism
Growth Inhibitors - pharmacology
Individualized Instruction
Interleukin-6
Janus Kinase 1
Leukemia Inhibitory Factor
Leukemia Inhibitory Factor Receptor alpha Subunit
Ligands (Biochemistry)
Lymphokines - metabolism
Lymphokines - pharmacology
Mammals
Membrane Glycoproteins - metabolism
Molecular embryology
Nerve Growth Factors - pharmacology
Nerve Tissue Proteins - metabolism
Nerve Tissue Proteins - pharmacology
Nervous system
Neural stem cells
Neurons
Phosphorylation
Plasmids
Platelet-Derived Growth Factor - pharmacology
Protein precursors
Protein-Tyrosine Kinases - metabolism
Rats
Receptor Protein-Tyrosine Kinases - metabolism
Receptor, Ciliary Neurotrophic Factor
Receptors, Cytokine - metabolism
Receptors, Nerve Growth Factor - metabolism
Receptors, OSM-LIF
Signal Transduction
STAT1 Transcription Factor
STAT3 Transcription Factor
Stem cells
Stem Cells - cytology
Trans-Activators - metabolism
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Summary:A mechanism by which members of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory factor cytokine family regulate gliogenesis in the developing mammalian central nervous system was characterized. Activation of the CNTF receptor promoted differentiation of cerebral cortical precursor cells into astrocytes and inhibited differentiation of cortical precursors along a neuronal lineage. Although CNTF stimulated both the Janus kinase-signal transducer and activator of transcription (JAK-STAT) and Ras-mitogen-activated protein kinase signaling pathways in cortical precursor cells, the JAK-STAT signaling pathway selectively enhanced differentiation of these precursors along a glial lineage. These findings suggest that cytokine activation of the JAK-STAT signaling pathway may be a mechanism by which cell fate is controlled during mammalian development.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.278.5337.477