Changes in Regional Cerebral Blood Flow Related to Line Bisection Discrimination and Visual Attention Using HMPAO-SPECT

Behavioral tasks requiring visual–spatial discrimination such as line bisection are used clinically to assess right hemisphere function, yet the anatomical substrate of line bisection has yet to be elucidated by functional imaging. In the current study, nine right-handed, healthy adult subjects unde...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 1997-08, Vol.6 (2), p.139-144
Main Authors: Marshall, Randolph S., Lazar, Ronald M., Van Heertum, Ronald L., Esser, Peter D., Perera, Gerard M., Mohr, J.P.
Format: Article
Language:English
Subjects:
Adult
Attention - physiology
Brain - anatomy & histology
Brain - diagnostic imaging
Cerebrovascular Circulation - physiology
Discrimination (Psychology) - physiology
Female
Functional Laterality - physiology
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Space Perception - physiology
Technetium Tc 99m Exametazime
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
Vision, Ocular - physiology
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Summary:Behavioral tasks requiring visual–spatial discrimination such as line bisection are used clinically to assess right hemisphere function, yet the anatomical substrate of line bisection has yet to be elucidated by functional imaging. In the current study, nine right-handed, healthy adult subjects underwent split-dose technetium-99m-hexamethylpropylene amine oxime single photon emission tomography during performance of two visual tasks. Statistical parametric maps that represented significant changes in regional cerebral blood flow (rCBF) for each task were generated. Increases in rCBF were seen in the right dorsolateral prefrontal cortex, the insula, and the superior temporal lobe with a line-bisection discrimination task, whereas increases in the visual association areas, the posterior cingulate gyrus bilaterally, and the anterior cingulate gyrus on the right were seen with a similar control task which required sustained visual attention, but no visual spatial discrimination. We conclude that distinct areas in the nondominant hemisphere can be shown to be active during performance of line-bisection discrimination and sustained visual attention.
ISSN:1053-8119
1095-9572
DOI:10.1006/nimg.1997.0283