A NOVEL SERIES OF MILBEMYCIN ANTIBIOTICS FROM STREPTOMYCES STRAIN E225: I. DISCOVERY, FERMENTATION AND ANTHELMINTIC ACTIVITY

A novel series of milbemycin antibiotics were produced by soil isolate, strain E225 which was shown to be a Streptomyces species. The antibiotics displayed anthelmintic activity against Trichostrongylus colubriformis in the gerbil. Two of the compounds, VM 44857 and VM 44866 were shown to be potent...

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Bibliographic Details
Published in:Journal of antibiotics 1989/11/25, Vol.42(11), pp.1593-1598
Main Authors: HOOD, J. D., BANKS, R. M., BREWER, M. D., FISH, J. P., MANGER, B. R., POULTON, M. E.
Format: Article
Language:English
Subjects:
Animals
anthelmintic agents
Anthelmintics - therapeutic use
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Biological and medical sciences
biological control
Chromatography, High Pressure Liquid
Fermentation
Gerbillinae
Haemonchus - drug effects
Macrolides
Medical sciences
milbemycin
Molecular Structure
Nematode Infections - drug therapy
Nematode Infections - veterinary
Pharmacology. Drug treatments
Sheep
Sheep Diseases - drug therapy
Streptomyces - metabolism
Trichostrongylosis - drug therapy
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Summary:A novel series of milbemycin antibiotics were produced by soil isolate, strain E225 which was shown to be a Streptomyces species. The antibiotics displayed anthelmintic activity against Trichostrongylus colubriformis in the gerbil. Two of the compounds, VM 44857 and VM 44866 were shown to be potent anthelmintics against mixed nematode infections in sheep.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.42.1593