Seroprevalence of Human Papillomavirus Types 6 and 16 Capsid Antibodies in Homosexual Men

Human papillomavirus (HPV) has been implicated in the pathogenesis of anal carcinoma, which is increased in homosexual men. Little is known about the serologic response to HPV in normal or immunosuppressed men; therefore, HIV-infected and -uninfected homosexual men were screened for HPV-6 and -16 ca...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-09, Vol.176 (3), p.625-631
Main Authors: Hagensee, Michael E., Kiviat, Nancy, Critchlow, Cathy W., Hawes, Stephen E., Kuypers, Jane, Holte, Sarah, Galloway, Denise A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - immunology
AIDS-Related Opportunistic Infections - virology
AIDS/HIV
Antibodies
Antibodies, Viral - blood
Biological and medical sciences
Capsid
Capsid - immunology
Condylomata acuminata
DNA, Viral
Enzyme-Linked Immunosorbent Assay
Epidemiology
Fundamental and applied biological sciences. Psychology
HIV
Homosexuality, Male
Human papillomavirus 16
Human papillomavirus 6
Human viral diseases
Humans
Infections
Infectious diseases
Major Articles
Male
Medical sciences
Men
Microbiology
Middle Aged
Papillomaviridae - genetics
Papillomaviridae - immunology
Papillomavirus Infections - complications
Papillomavirus Infections - epidemiology
Papillomavirus Infections - immunology
Papillomavirus Infections - virology
Polymerase chain reaction
Prevalence
Tumor Virus Infections - complications
Tumor Virus Infections - epidemiology
Tumor Virus Infections - immunology
Tumor Virus Infections - virology
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Virology
Warts
Warts - complications
Warts - epidemiology
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Description
Summary:Human papillomavirus (HPV) has been implicated in the pathogenesis of anal carcinoma, which is increased in homosexual men. Little is known about the serologic response to HPV in normal or immunosuppressed men; therefore, HIV-infected and -uninfected homosexual men were screened for HPV-6 and -16 capsid antibodies. HIV-infected men had increased HPV DNA detection but did not significantly differ in the prevalence of serum HPV antibodies. HPV-6 DNA detection and the presence of anal warts were significantly correlated with serum antibody overall and in the HIV-infected subgroup. HPV-16 DNA detection was not significantly correlated with serum antibody overall or in either subgroup; however, HIV-infected men with high-grade anal squamous intraepithelial lesions were significantly more likely to have HPV-16 antibodies. HIV-infected men are able to generate an antibody response to HPV, and a lack of serum HPV antibodies cannot explain the increased HPV-associated disease seen in HIV-infected men.
ISSN:0022-1899
1537-6613
DOI:10.1086/514082