Fractal analysis of striatal dopamine re-uptake sites

Spatial variation in regional blood flow, metabolism and receptor density within the brain and in other organs is measurable even with a low spatial resolution technique such as emission tomography. It has been previously shown that the observed variance increases with increasing number of subregion...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1997-09, Vol.24 (9), p.1085-1090
Main Authors: KUIKKA, J. T, TIIHONEN, J, KARHU, J, BERGSTRÖM, K. A, RÄSÄNEN, P
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carrier Proteins - metabolism
Cocaine - analogs & derivatives
Corpus Striatum - diagnostic imaging
Corpus Striatum - metabolism
Dopamine - metabolism
Dopamine Plasma Membrane Transport Proteins
Female
Fractals
Humans
Investigative techniques, diagnostic techniques (general aspects)
Iodine Radioisotopes
Least-Squares Analysis
Male
Medical sciences
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins
Nervous system
Radionuclide investigations
Tomography, Emission-Computed, Single-Photon - methods
Tomography, Emission-Computed, Single-Photon - statistics & numerical data
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Summary:Spatial variation in regional blood flow, metabolism and receptor density within the brain and in other organs is measurable even with a low spatial resolution technique such as emission tomography. It has been previously shown that the observed variance increases with increasing number of subregions in the organ/tissue studied. This resolution-dependent variance can be described by fractal analysis. We studied striatal dopamine re-uptake sites in 39 healthy volunteers with high-resolution single-photon emission tomography using iodine-123 labelled 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([123I]beta-CIT). The mean fractal dimension was 1.15+/-0.07. The results indicate that regional striatal dopamine re-uptake sites involve considerable spatial heterogeneity which is higher than the uniform density (dimension=1.00) but much lower than complete randomness (dimension=1.50). There was a gender difference, with females having a higher heterogeneity in both the left and the right striatum. In addition, we found striatal asymmetry (left-to-right heterogeneity ratio of 1.19+/-0.15; P
ISSN:0340-6997
1619-7089
DOI:10.1007/BF01254238