The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions

Ligand-induced activation of receptor tyrosine kinases (RTK) results in the initiation of diverse cellular pathways, including proliferation, differentiation and cell migration. The ErbB family of RTKs represents a model for signal diversification through the formation of homo- and heterodimeric rec...

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Bibliographic Details
Published in:FEBS Letters 1997-06, Vol.410 (1), p.83-86
Main Authors: Alroy, Iris, Yarden, Yosef
Format: Article
Language:English
Subjects:
Animals
Cell Transformation, Neoplastic
Embryonic and Fetal Development - physiology
Epidermal Growth Factor - metabolism
ErbB
ErbB Receptors - metabolism
Growth factor
Humans
Ligands
Proto-Oncogene Proteins - metabolism
Receptor
Receptor, ErbB-2 - metabolism
Receptor, ErbB-3
Receptor, ErbB-4
Signal Transduction
Tyrosine kinase
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Summary:Ligand-induced activation of receptor tyrosine kinases (RTK) results in the initiation of diverse cellular pathways, including proliferation, differentiation and cell migration. The ErbB family of RTKs represents a model for signal diversification through the formation of homo- and heterodimeric receptor complexes. Each dimeric receptor complex will initiate a distinct signaling pathway by recruiting a different set of Src homology 2- (SH2-) containing effector proteins. Further complexity is added due to the existence of an oncogenic receptor that enhances and stabilizes dimerization but has no ligand (ErbB-2), and a receptor that can recruit novel SH-2-containing proteins, but is itself devoid of kinase activity (ErbB-3). The resulting signaling network has important implications for embryonic development and malignant transformation.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(97)00412-2