Human T-cell leukemia viruses: epidemiology, biology, and pathogenesis

The human T-cell lymphotropic viruses type I and type II are closely related human retroviruses that have similar biological properties, genetic organization and tropism for T lymphocytes. Along with the simian T-cell lymphoma virus type I, they define the group of retroviruses known as the primate...

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Bibliographic Details
Published in:Blood reviews 1997-06, Vol.11 (2), p.91-104
Main Authors: Ferreira, O.C., Planelles, V., Rosenblatt, J.D.
Format: Article
Language:English
Subjects:
Adult
AIDS/HIV
Animals
Biological and medical sciences
Gene Products, rex - metabolism
Gene Products, tax - metabolism
Hematologic and hematopoietic diseases
HTLV-I Infections - epidemiology
HTLV-I Infections - genetics
HTLV-I Infections - transmission
HTLV-II Infections - epidemiology
HTLV-II Infections - genetics
HTLV-II Infections - transmission
Human T-lymphotropic virus 1 - genetics
Human T-lymphotropic virus 1 - pathogenicity
Human T-lymphotropic virus 2 - genetics
Human T-lymphotropic virus 2 - pathogenicity
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
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Summary:The human T-cell lymphotropic viruses type I and type II are closely related human retroviruses that have similar biological properties, genetic organization and tropism for T lymphocytes. Along with the simian T-cell lymphoma virus type I, they define the group of retroviruses known as the primate T-cell leukemia/lymphoma viruses. Initially identified in 1980, the human T-cell lymphotropic virus type I has been implicated as the etiologic agent of adult T-cell leukemia/lymphoma and of a degenerative neurologic disorder known as tropical spastic paraparesis or human T-cell lymphotropic virus type I-associated myelopathy. The intriguing link between human T-cell lymphotropic virus type, T-cell malignancy, and a totally unrelated and non-overlapping neurological disorder suggests divergent and unique pathogenetic mechanisms. This review will address the epidemiology, molecular biology, and pathogenesis of human T-cell leukemia viruses.
ISSN:0268-960X
1532-1681
DOI:10.1016/S0268-960X(97)90015-1