Neoadjuvant intra-arterial polychemotherapy of locally advanced rectal cancer

In order to evaluate the usefulness of pre-operative intra-arterial selective polychemotherapy (PIASP), we carried out a retrospective study of 107 patients (65 males, 42 females) with locally advanced rectal cancer (LARC) (pT3-4 N0-1 M0), who were treated between 1988 and 1991. Fifty-two patients (...

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Bibliographic Details
Published in:European journal of surgical oncology 1997-06, Vol.23 (3), p.228-232
Main Authors: Braun, E.M., Kikot, V.A., Ugrinov, O.G., Lishchishina, E.M.
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Carcinoma - blood supply
Carcinoma - drug therapy
Carcinoma - pathology
Carcinoma - surgery
Chemotherapy
Chemotherapy, Adjuvant
Female
Humans
Infusions, Intra-Arterial
intra-arterial chemotherapy
Male
Medical sciences
Middle Aged
Neovascularization, Pathologic
Pharmacology. Drug treatments
rectal cancer
Rectal Neoplasms - blood supply
Rectal Neoplasms - drug therapy
Rectal Neoplasms - pathology
Rectal Neoplasms - surgery
Retrospective Studies
survival
Survival Analysis
Time Factors
Treatment Outcome
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Summary:In order to evaluate the usefulness of pre-operative intra-arterial selective polychemotherapy (PIASP), we carried out a retrospective study of 107 patients (65 males, 42 females) with locally advanced rectal cancer (LARC) (pT3-4 N0-1 M0), who were treated between 1988 and 1991. Fifty-two patients (MG) underwent PIASP (Adriablastin 60–90 mg, fluorouracil 3–4 g) with subsequent radical surgery. Fifty-five patients (R0) received surgery alone. Angiographic findings after PIASP showed ∼ 50–70% reduction in the vascular network in the tumour and surrounding tissues. A post-operative morphological study confirmed the considerable tumour dystrophy, necrobiosis and necrosis. Comparative statistical analysis in two patient groups showed that overall 5-year survival was significantly better in MG (64.76 ± 1.85%) than in R0 (38.23 ± 1.74%; ξ 2 = 9.1; P
ISSN:0748-7983
1532-2157
DOI:10.1016/S0748-7983(97)92412-4